MitoQ for Type 2 Diabetes
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores a new method to help individuals with Type 2 Diabetes manage blood pressure during exercise. Researchers aim to improve blood vessel function and reduce the risk of serious heart problems by using a special antioxidant called MitoQ (mitoquinol mesylate). The trial will compare MitoQ to a placebo (a look-alike pill with no active ingredient) to determine its effectiveness. Individuals with Type 2 Diabetes who have had the condition for more than six months and maintain stable medication routines may be ideal candidates. As an unphased trial, this study offers participants the opportunity to contribute to innovative research that could lead to better health outcomes.
Do I need to stop my current medications for the trial?
The trial does not specify if you need to stop your current medications, but it requires that your medications for managing Type 2 Diabetes have been stable for more than 6 months.
Is there any evidence suggesting that MitoQ is likely to be safe for humans?
Research has shown that MitoQ, an antioxidant that works within cells, is generally safe for use. In one study, participants who took MitoQ did not experience higher levels of kidney damage compared to those who took a placebo, indicating that MitoQ likely does not harm the kidneys. Another study found that MitoQ improved heart function, and participants tolerated it well without serious side effects. These findings suggest that MitoQ could be a safe option for those considering participation in a clinical trial.12345
Why do researchers think this study treatment might be promising for diabetes?
Unlike the standard treatments for type 2 diabetes, such as metformin or insulin, MitoQ is an antioxidant that specifically targets the mitochondria. This unique mechanism is exciting because it aims to reduce oxidative stress within the cells, which is thought to play a role in the progression of diabetes. By directly targeting the mitochondria, MitoQ could potentially address the root causes of cellular dysfunction in diabetes, offering a novel approach that differs from current therapies that primarily focus on managing blood sugar levels. Researchers are hopeful that this innovative strategy might improve overall cell health and provide benefits beyond traditional glucose control.
What evidence suggests that MitoQ might be an effective treatment for Type 2 Diabetes?
Research has shown that MitoQ, an antioxidant that operates in the mitochondria, may enhance blood vessel function by reducing oxidative stress. Oxidative stress occurs when free radicals outnumber antioxidants, potentially damaging cells. One study found MitoQ to be 24% more effective than CoQ10 in lowering harmful hydrogen peroxide levels in mitochondria, thereby protecting cells. Another study demonstrated that MitoQ improved heart function, suggesting it might help prevent heart problems. These findings indicate that MitoQ could aid individuals with Type 2 Diabetes in exercising more effectively and reducing heart risks by protecting cells and enhancing blood vessel function. Participants in this trial will receive either MitoQ or a placebo to assess its effectiveness in these areas.16789
Who Is on the Research Team?
William E Hughes, Ph.D.
Principal Investigator
Medical College of Wisconsin
Are You a Good Fit for This Trial?
This trial is for individuals with Type 2 Diabetes who may experience high blood pressure during exercise, potentially increasing their risk of heart-related issues. The study aims to understand if poor blood vessel function and cellular damage contribute to this problem.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive either MitoQ, a mitochondrial target antioxidant, or a placebo, and undergo handgrip exercise and post-exercise circulatory occlusion to measure blood pressure and heart rate responses.
Follow-up
Participants are monitored for safety and effectiveness after treatment, with measurements of endothelial function, plasma MitoQ concentration, and muscle tissue oxygenation.
What Are the Treatments Tested in This Trial?
Interventions
- MitoQ (mitoquinol mesylate)
Find a Clinic Near You
Who Is Running the Clinical Trial?
Medical College of Wisconsin
Lead Sponsor