Collagen Peptides for Osteoarthritis
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores whether collagen peptides, such as SOLUGEL, can alleviate symptoms and enhance joint health in people with osteoarthritis. Participants will be divided into two groups: one will take collagen peptides, and the other will take a placebo (a harmless pill with no active treatment) for 24 weeks. The study seeks individuals diagnosed with osteoarthritis who plan to undergo knee replacement surgery at UAMS soon and live near Little Rock. As an unphased trial, it offers participants the chance to contribute to research that could improve joint health for many.
Is there any evidence suggesting that collagen peptides are likely to be safe for humans?
Research shows that collagen peptides are generally safe. Studies have found that these supplements do not increase the risk of stopping treatment or cause more side effects than a placebo. Some people report mild stomach issues and headaches, but these are uncommon. One study found no side effects, suggesting that collagen peptides are safe and well-tolerated. Overall, they appear to be a good option for people with osteoarthritis, with few side effects reported.12345
Why are researchers excited about this trial?
Collagen Peptides, specifically SOLUGEL, is unique for osteoarthritis treatment because it leverages a different approach through its active ingredient, collagen peptides. Unlike standard care options like NSAIDs and corticosteroids, which primarily focus on reducing inflammation and pain, collagen peptides aim to support joint health by potentially enhancing cartilage structure. Researchers are excited about this treatment because it offers a promising avenue to not just alleviate symptoms but also address one of the underlying causes of osteoarthritis, potentially leading to longer-term joint health improvements.
What evidence suggests that collagen peptides might be an effective treatment for osteoarthritis?
Research has shown that collagen peptides, which participants in this trial may receive, can help reduce pain in people with knee osteoarthritis. Studies have found that individuals taking collagen peptides experienced significant pain relief compared to those taking a placebo. In one study, participants who took 3,000 mg daily for 180 days showed noticeable improvements in joint pain and function. Other research supports these findings, indicating that collagen products are both effective and safe for treating osteoarthritis. Overall, the evidence suggests that collagen peptides might help ease osteoarthritis symptoms.36789
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Baseline Assessment
Baseline assessments including DXA scan, blood sample collection, and initial treatment allocation
Treatment
Participants receive collagen peptides or placebo, with regular assessments and physical therapy
Surgery and Immediate Post-Surgery
Total Knee Arthroplasty surgery and collection of tissue samples
Follow-up
Participants are monitored for safety and effectiveness after treatment, including final assessments
What Are the Treatments Tested in This Trial?
Interventions
- SOLUGEL
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Placebo Group
10 grams per day for 24 weeks
10 grams per day maltodextrin for 24 weeks
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Arkansas
Lead Sponsor
Tessenderlo Group
Collaborator
Citations
Analgesic efficacy of collagen peptide in knee osteoarthritis
Our findings demonstrate significant pain relief in patients with knee osteoarthritis who received collagen peptides compared to those who received placebo.
Oral administration of hydrolyzed collagen alleviates pain ...
Our findings reveal significant pain relief in patients with knee OA who received collagen peptides compared with those in the placebo group. The analgesic ...
Efficacy and safety of collagen derivatives for osteoarthritis
In conclusion, collagen derivatives are effective and safe for osteoarthritis treatment. These derivatives can be used as dietary supplements for pain reduction ...
Efficacy of combined undenatured type II collagen and ...
Combined UC-II and hydrolysed collagen supplementation over 12 weeks did not demonstrate superior efficacy compared with that of the placebo in ...
Efficacy and safety of low-molecular-weight collagen ...
Notably, the primary outcome of WOMAC pain demonstrated a clinically meaningful improvement, with a standardized mean difference of 0.46— ...
Efficacy and safety of low-molecular-weight collagen peptides ...
Abstract. Introduction. Knee osteoarthritis (OA) is a common degenerative joint disease with limited safe, long-term treatment options.
Efficacy and safety of collagen derivatives for osteoarthritis
Collagen derivatives were safe; they did not increase the risk of withdrawal or adverse events compared with the control. The trial sequential analyses ...
Commentary: Efficacy and safety of low-molecular-weight ...
Commentary: Efficacy and safety of low-molecular-weight collagen peptides in knee osteoarthritis: a randomized, double-blind, placebo-controlled trial.
Joint Pain? Why Collagen Peptides Work & Medically ... - Ubie
Collagen peptides can modestly reduce joint pain and stiffness in mild to moderate osteoarthritis and support connective tissue, ...
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