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N/A

Ozone Exposure for Air Pollution-related Lung Injury

N/A

Recruiting

Led By Howard M Kipen, MD

Research Sponsored by Rutgers, The State University of New Jersey

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up within 3 days of exposure

Awards & highlights

Study Summary

This trial will examine how ozone exposure affects the lungs, with subjects exposed to clean air and ozone in two visits. Sputum samples will be taken to measure macrophage activity.

Who is the study for?

This trial is for individuals vaccinated against COVID-19, without recent respiratory symptoms or a history of smoking in the past 5 years. They must not have diabetes, pregnancy, HIV infection, certain orthopedic conditions, daily use of specific antioxidant supplements (except multivitamins), cardiovascular disease, or respiratory disease.Check my eligibility

What is being tested?

The study aims to understand lung injury from ozone by comparing effects of filtered air and ozone exposure on participants. Each participant will undergo two sessions with at least a two-week gap and provide sputum samples for macrophage activity analysis.See study design

What are the potential side effects?

While the trial involves clean air and ozone exposure rather than medication intake, potential side effects may include coughing due to sputum production and temporary respiratory discomfort following ozone inhalation.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ within 3 days of exposure

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~within 3 days of exposure

This trial's timeline: 3 weeks for screening, Varies for treatment, and within 3 days of exposure for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Metabolic activity of inflammatory cells in induced sputum

Trial Design

2Treatment groups

Experimental Treatment

Group I: Ozone, Then Clean AirExperimental Treatment2 Interventions

Subjects will be exposed to 0.2 ppm ozone for 3 hours at the first exposure visit and clean air for 3 hours at the second exposure visit. The visits will be at least 2 weeks apart.

Group II: Clean Air, Then OzoneExperimental Treatment2 Interventions

Subjects will be exposed to clean air for 3 hours at the first exposure visit and 0.2ppm ozone for 3 hours at the second exposure visit. The visits will be at least 2 weeks apart.

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Rutgers, The State University of New JerseyLead Sponsor

429 Previous Clinical Trials

64,112 Total Patients Enrolled

2 Trials studying Air Pollution

159 Patients Enrolled for Air Pollution

National Institute of Environmental Health Sciences (NIEHS)NIH

284 Previous Clinical Trials

1,232,617 Total Patients Enrolled

5 Trials studying Air Pollution

784 Patients Enrolled for Air Pollution

Howard M Kipen, MDPrincipal InvestigatorRutgers School of Public Health

Media Library

Clean Air (N/A) Clinical Trial Eligibility Overview. Trial Name: NCT05794087 — N/A

Air Pollution Research Study Groups: Clean Air, Then Ozone, Ozone, Then Clean Air

Air Pollution Clinical Trial 2023: Clean Air Highlights & Side Effects. Trial Name: NCT05794087 — N/A

Clean Air (N/A) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05794087 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this medical study accept participants who are below the age of 80?

"This experiment is currently accepting applicants aged between 18 and 40 years old."

Answered by AI

What criteria must be fulfilled in order to join this medical experiment?

"Eligibility criteria for this trial call for patients with air pollution and between 18 to 40 years of age. Around 120 candidates are being sought after by the medical team leading this study."

Answered by AI

How many volunteers are being accepted for this research endeavor?

"Affirmative. Clinicaltrials.gov lists indicate that the research is actively looking for participants - it was initially posted on February 7th 2023, and last updated March 20th of this year. 120 patients are expected to be recruited from a single location."

Answered by AI

Is recruitment for this research still open?

"Affirmative. Evidence from clinicaltrials.gov verifies that this medical trial, which was initially posted on February 7th 2023, is actively recruiting participants. The research team aspires to enrol 120 patients across a single site."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

The Role of Macrophage Activation in Lung Injury Following Ozone Exposure

Howard M. Kipen, MD, MPH 2023. "The Role of Macrophage Activation in Lung Injury Following Ozone Exposure". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05794087.