ECT device set to stimularte at a dose estimated to be below seizure threshold for Bipolar Disorder
Study Summary
This trial is studying a treatment called TEST for people with major depression that has not been relieved by current treatments.
- Bipolar Disorder
- Major Depression
- Depression
Treatment Effectiveness
Phase-Based Effectiveness
Study Objectives
2 Primary · 2 Secondary · Reporting Duration: Baseline, End of Phase II (approximately 2 weeks) and end of Phase III (4-13 weeks)and at 2 and 4 weeks post treatment course
Trial Safety
Phase-Based Safety
Trial Design
2 Treatment Groups
Transcranial Electric Stimulation Therapy (TEST)
1 of 2
Sham TEST
1 of 2
Experimental Treatment
Non-Treatment Group
35 Total Participants · 2 Treatment Groups
Primary Treatment: ECT device set to stimularte at a dose estimated to be below seizure threshold · Has Placebo Group · N/A
Trial Logistics
Trial Timeline
Who is running the clinical trial?
Eligibility Criteria
Age 25 - 64 · All Participants · 0 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:- Regenold, William T., Robert J. Noorani, Deborah Piez, and Palak Patel. 2015. “Nonconvulsive Electrotherapy for Treatment Resistant Unipolar and Bipolar Major Depressive Disorder: A Proof-of-concept Trial”. Brain Stimulation. Elsevier BV. doi:10.1016/j.brs.2015.06.011.
- Sackeim, Harold A.. 2015. “Is the Seizure an Unnecessary Component of Electroconvulsive Therapy? A Startling Possibility”. Brain Stimulation. Elsevier BV. doi:10.1016/j.brs.2015.07.026.
- Quante, Arnim, Alexander Luborzewski, Eva-Lotta Brakemeier, Angela Merkl, Heidi Danker-Hopfe, and Malek Bajbouj. 2011. “Effects of 3 Different Stimulus Intensities of Ultrabrief Stimuli in Right Unilateral Electroconvulsive Therapy in Major Depression: A Randomized, Double-blind Pilot Study”. Journal of Psychiatric Research. Elsevier BV. doi:10.1016/j.jpsychires.2010.08.006.
- Sackeim HA. Is the Seizure an Unnecessary Component of Electroconvulsive Therapy? A Startling Possibility. Brain Stimul. 2015 Sep-Oct;8(5):851-4. doi: 10.1016/j.brs.2015.07.026. Epub 2015 Jul 17. No abstract available.
- 2022. "Transcranial Electric Stimulation Therapy (TEST) for Treatment Resistant Depression (TRD". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05172271.
Frequently Asked Questions
May I join this medical research initiative?
"Eligible candidates have been diagnosed with manic disorder and are between 25 to 64 years old. This medical trial is in need of 35 participants." - Anonymous Online Contributor
Is there still availability to join this research experiment?
"Yes, the information on clinicialtrials.gov indicates that this trial is actively recruiting patients. The research was initially posted on October 6th 2022 and last updated September 30th of the same year. 35 participants need to be recruited from a single medical centre." - Anonymous Online Contributor
Does this trial include elderly participants?
"This trial is open to applicants aged 25-64. For those younger and older, there are 414 trials available for minors and 1497 clinical studies designed specifically with seniors in mind." - Anonymous Online Contributor
How many participants are joining this research endeavor?
"Indeed, according to the clinicaltrials.gov website, this study is still in need of participants. First posted on October 6th 2022 and edited most recently on September 30th 2022, it seeks 35 individuals from a single medical facility." - Anonymous Online Contributor