An Innovative Master Platform for Clinical Trials in Mood Disorders
(ENABLE Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
Mood disorders such as depression and bipolar disorder affect over 350 million people around the world. While several effective treatments exist, it is often difficult to match the right treatment to an individual person. Repeated efforts to find the right treatment contribute to poor functioning, low quality of life, and prolongs the time it takes to get well. Most areas of medicine are able to use 'biomarkers' or clinical tests, blood tests, or imaging to help diagnose and treat illness. The search for biomarkers in mood disorders is advancing, but one roadblock to progress is the lack of large, standardized studies of mood disorders that are needed to accurately identify biomarkers. The aim of the ENABLE platform is to provide the Canadian neuroscience community a standardized way of collecting biomarker data from individuals with a range of mood disorders symptoms. In addition, this 'master clinical trial platform' framework will provide a pool of participants who can be recruited into biomarker-based clinical trials.
Who Is on the Research Team?
Benicio N Frey
Principal Investigator
St. Joseph's Healthcare Hamilton
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Tier 1 Assessment
Participants complete clinical assessments, including clinician-administered and self-report measures
Tier 2 Assessment
Participants provide blood samples, undergo neuroimaging procedures (MRI and EEG), and wear an actigraphy device for two weeks
Follow-up
Participants are monitored for safety and effectiveness after assessments
What Are the Treatments Tested in This Trial?
Find a Clinic Near You
Who Is Running the Clinical Trial?
St. Joseph's Healthcare Hamilton
Lead Sponsor
Simon Fraser University
Collaborator
University of British Columbia
Collaborator
Unity Health Toronto
Collaborator
Centre for Addiction and Mental Health
Collaborator
Queen's University
Collaborator
University of Ottawa
Collaborator
University of Calgary
Collaborator
McGill University
Collaborator
Nova Scotia Health Authority
Collaborator