54 Participants Needed

Transcranial Magnetic Stimulation for Depression

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JC
Overseen ByJoan Camprodon, MD, PhD, MPH
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Massachusetts General Hospital
Must be taking: TMS
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)
Approved in 3 JurisdictionsThis treatment is already approved in other countries

What You Need to Know Before You Apply

What is the purpose of this trial?

This is an observational neuroimaging study assessing the effects of TMS on the brains of patients with unipolar depression.

Who Is on the Research Team?

JC

Joan Camprodon, MD, MPH, PhD

Principal Investigator

Massachusetts General Hospital

Are You a Good Fit for This Trial?

This trial is for men and women aged 18-80 with a diagnosis of depression who need Transcranial Magnetic Stimulation (TMS) as part of their psychiatric care. It's not suitable for those with MRI contraindications, other primary mental health conditions like schizophrenia, active substance abuse in the past 3 months, or severe medical illnesses.

Inclusion Criteria

I have been diagnosed with depression.
I need TMS treatment for my mental health condition.

Exclusion Criteria

Comorbid DSM-IV primary diagnoses of schizoaffective disorder, schizophrenia or dementia
Substance use disorder (abuse or dependence) with active use within the last 3 months
MRI contraindications as determined by MGH department of radiology.
See 1 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive Transcranial Magnetic Stimulation (TMS) and are scanned using fcMRI before and after the treatment

6 weeks

Follow-up

Participants are monitored for changes in functional connectivity and clinical measures for depression severity and memory

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Transcranial Magnetic Stimulation
Trial Overview The study observes how TMS affects the brain in patients with unipolar depression. This non-invasive treatment uses magnetic fields to stimulate nerve cells in the brain and is being studied using neuroimaging techniques.
How Is the Trial Designed?
1Treatment groups
Experimental Treatment
Group I: Unipolar DepressionExperimental Treatment1 Intervention

Transcranial Magnetic Stimulation is already approved in United States, Canada, European Union for the following indications:

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Approved in United States as Transcranial Magnetic Stimulation for:
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Approved in Canada as Transcranial Magnetic Stimulation for:
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Approved in European Union as Transcranial Magnetic Stimulation for:

Find a Clinic Near You

Who Is Running the Clinical Trial?

Massachusetts General Hospital

Lead Sponsor

Trials
3,066
Recruited
13,430,000+
Unbiased ResultsWe believe in providing patients with all the options.
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