Cognitive Remediation Therapy for Depression
(CogRemVet Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests a new therapy called Cognitive Remediation Therapy to assist Veterans with depression who have attempted suicide. The focus is on enhancing cognitive skills and problem-solving to manage real-life stress that may trigger suicidal thoughts. Delivered online over 10 weeks, the therapy aims to improve mental health and quality of life. Veterans with depression, a suicide attempt in the past year, and who are currently in therapy might be suitable candidates. As an unphased trial, this study provides Veterans with a unique opportunity to access innovative therapy that could enhance their mental well-being.
Will I have to stop taking my current medications?
The trial protocol does not specify whether you need to stop taking your current medications. However, since participants must be in psychotherapy treatment as usual, it seems likely that you can continue your current treatments.
What prior data suggests that this cognitive remediation therapy is safe for Veterans with depression?
In earlier studies, the Neuropsychological Educational Approach to Cognitive Remediation (NEAR) has been used with individuals who have mental health conditions, yielding encouraging results. NEAR aims to improve thinking skills, which are essential for learning and problem-solving.
Research has shown that NEAR is generally well-tolerated, with most participants experiencing no serious side effects. Participants in studies completed sessions without major issues, indicating that the treatment is safe to try. However, as this is a newer approach for treating depression linked with suicidal risk, further research is necessary to fully understand all possible effects.
Prospective participants should discuss any concerns with a healthcare provider, who can offer advice based on personal health needs.12345Why are researchers excited about this trial?
Researchers are excited about the Cognitive Remediation plus Bridging technique for depression because it focuses on improving cognitive functions, like memory and attention, which are often impaired in people with depression. Unlike traditional talk therapy or medication that primarily targets mood symptoms, this approach uses structured cognitive exercises to directly enhance brain function. This method is particularly promising for veterans at high risk for suicide, as it aims to provide them with tools for better cognitive control and decision-making, potentially leading to improved mental health outcomes.
What evidence suggests that this cognitive remediation therapy is effective for depression?
Research has shown that the Neuropsychological Educational Approach to Cognitive Remediation (NEAR) can enhance thinking skills and alleviate symptoms of depression. Studies have found that NEAR improves mental functioning and increases well-being in individuals with depression. This treatment targets brain abilities such as attention, memory, and problem-solving, which depression often affects. Although further research is necessary, early results suggest this approach may assist those at high risk for suicide by enhancing their ability to manage stress and daily challenges. Participants in this trial will receive the Cognitive Remediation plus Bridging intervention to evaluate its feasibility and effectiveness.23567
Who Is on the Research Team?
Erin A Hazlett-Oakes, PhD
Principal Investigator
James J. Peters Veterans Affairs Medical Center
Are You a Good Fit for This Trial?
This trial is for U.S. Veterans aged 18-60 with major depressive disorder and a history of suicide attempts within the past year. They must have current suicidal thoughts without immediate plans to act on them, be in ongoing psychotherapy, and score high on rumination measures. Women are encouraged to participate, aiming for at least 30% female participants.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive a 10-week (20 session) cognitive remediation intervention via telehealth
Post-treatment Assessment
Post-treatment assessments of neurocognitive, clinical, social, and real-world functioning are conducted
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Neuropsychological Educational Approach to Cognitive Remediation (NEAR, termed Cognitive Remediation plus Bridging)
Find a Clinic Near You
Who Is Running the Clinical Trial?
VA Office of Research and Development
Lead Sponsor