Study Summary
This trial will study if texting can help improve care for heart attack patients and reduce hospital readmissions.
Treatment Effectiveness
Effectiveness Progress
Study Objectives
1 Primary · 3 Secondary · Reporting Duration: Within one year of initial hospital presentation
Within one year of initial hospital presentation
Emergency Department presentation
Medication compliance
Physician visit
Re-hospitalization
Trial Safety
Safety Progress
Trial Design
3 Treatment Groups
Treatment group
1 of 3
Texting intervention group
1 of 3
Control group
1 of 3
Active Control
Experimental Treatment
Non-Treatment Group
250 Total Participants · 3 Treatment Groups
Primary Treatment: Texting intervention group · Has Placebo Group · N/A
Texting intervention group
Other
Experimental Group · 1 Intervention: Motivational texting · Intervention Types: OtherTreatment group
Other
ActiveComparator Group · 1 Intervention: Texting intervention · Intervention Types: OtherControl groupPlaceboComparator Group · 2 Interventions: Texting intervention, Control · Intervention Types: Other, Other
Trial Logistics
Trial Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: within one year of initial hospital presentation
Who is running the clinical trial?
Sunnybrook Health Sciences CentreLead Sponsor
607 Previous Clinical Trials
1,467,993 Total Patients Enrolled
11 Trials studying Coronary Artery Disease
3,947 Patients Enrolled for Coronary Artery Disease
Dennis Ko, MDPrincipal InvestigatorResearch Director
Eligibility Criteria
Age 18+ · All Participants · 3 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:References
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- Adler AJ, Martin N, Mariani J, Tajer CD, Owolabi OO, Free C, Serrano NC, Casas JP, Perel P. Mobile phone text messaging to improve medication adherence in secondary prevention of cardiovascular disease. Cochrane Database Syst Rev. 2017 Apr 29;4:CD011851. doi: 10.1002/14651858.CD011851.pub2. Review.
- Shariful Islam SM, Farmer AJ, Bobrow K, Maddison R, Whittaker R, Pfaeffli Dale LA, Lechner A, Lear S, Eapen Z, Niessen LW, Santo K, Stepien S, Redfern J, Rodgers A, Chow CK. Mobile phone text-messaging interventions aimed to prevent cardiovascular diseases (Text2PreventCVD): systematic review and individual patient data meta-analysis. Open Heart. 2019 Oct 9;6(2):e001017. doi: 10.1136/openhrt-2019-001017. eCollection 2019.
- Chow, Clara K., Julie Redfern, Graham S. Hillis, Jay Thakkar, Karla Santo, Maree L. Hackett, Stephen Jan, et al.. 2015. “Effect of Lifestyle-focused Text Messaging on Risk Factor Modification in Patients with Coronary Heart Disease”. Jama. American Medical Association (AMA). doi:10.1001/jama.2015.10945.
- Wong MK, Wang JT, Czarnecki A, Koh M, Tu JV, Schull MJ, Wijeysundera HC, Lau C, Ko DT. Factors associated with physician follow-up among patients with chest pain discharged from the emergency department. CMAJ. 2015 Mar 17;187(5):E160-8. doi: 10.1503/cmaj.141294. Epub 2015 Feb 23.
- 2. Canadian Institute for Health Information. CIHI Data Quality Study of Ontario Emergency Department Visits 2004-2005: Volume II of IV - Main Study Findings Ottawa, Ontario 2008.3.
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- Tu JV, Chu A, Rezai MR, Guo H, Maclagan LC, Austin PC, Booth GL, Manuel DG, Chiu M, Ko DT, Lee DS, Shah BR, Donovan LR, Sohail QZ, Alter DA. The Incidence of Major Cardiovascular Events in Immigrants to Ontario, Canada: The CANHEART Immigrant Study. Circulation. 2015 Oct 20;132(16):1549-1559. doi: 10.1161/CIRCULATIONAHA.115.015345. Epub 2015 Aug 31.
- Czarnecki A, Wang JT, Tu JV, Lee DS, Schull MJ, Lau C, Farkouh ME, Wijeysundera HC, Ko DT. The role of primary care physician and cardiologist follow-up for low-risk patients with chest pain after emergency department assessment. Am Heart J. 2014 Sep;168(3):289-95. doi: 10.1016/j.ahj.2014.05.016. Epub 2014 Jun 9.
- Huo X, Krumholz HM, Bai X, Spatz ES, Ding Q, Horak P, Zhao W, Gong Q, Zhang H, Yan X, Sun Y, Liu J, Wu X, Guan W, Wang X, Li J, Li X, Spertus JA, Masoudi FA, Zheng X. Effects of Mobile Text Messaging on Glycemic Control in Patients With Coronary Heart Disease and Diabetes Mellitus: A Randomized Clinical Trial. Circ Cardiovasc Qual Outcomes. 2019 Sep;12(9):e005805. doi: 10.1161/CIRCOUTCOMES.119.005805. Epub 2019 Aug 31.
- Ko DT, Alter DA, Guo H, Koh M, Lau G, Austin PC, Booth GL, Hogg W, Jackevicius CA, Lee DS, Wijeysundera HC, Wilkins JT, Tu JV. High-Density Lipoprotein Cholesterol and Cause-Specific Mortality in Individuals Without Previous Cardiovascular Conditions: The CANHEART Study. J Am Coll Cardiol. 2016 Nov 8;68(19):2073-2083. doi: 10.1016/j.jacc.2016.08.038.
- Leppin, Aaron L., Michael R. Gionfriddo, Maya Kessler, Juan Pablo Brito, Frances S. Mair, Katie Gallacher, Zhen Wang, et al.. 2014. “Preventing 30-day Hospital Readmissions”. JAMA Internal Medicine. American Medical Association (AMA). doi:10.1001/jamainternmed.2014.1608.
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- Czarnecki A, Chong A, Lee DS, Schull MJ, Tu JV, Lau C, Farkouh ME, Ko DT. Association between physician follow-up and outcomes of care after chest pain assessment in high-risk patients. Circulation. 2013 Apr 2;127(13):1386-94. doi: 10.1161/CIRCULATIONAHA.112.000737.
- Thakkar J, Kurup R, Laba TL, Santo K, Thiagalingam A, Rodgers A, Woodward M, Redfern J, Chow CK. Mobile Telephone Text Messaging for Medication Adherence in Chronic Disease: A Meta-analysis. JAMA Intern Med. 2016 Mar;176(3):340-9. doi: 10.1001/jamainternmed.2015.7667. Review.
- Jencks, Stephen F., Mark V. Williams, and Eric A. Coleman. 2009. “Rehospitalizations Among Patients in the Medicare Fee-for-service Program”. New England Journal of Medicine. Massachusetts Medical Society. doi:10.1056/nejmsa0803563.
- Jencks SF, Williams MV, Coleman EA. Rehospitalizations among patients in the Medicare fee-for-service program. N Engl J Med. 2009 Apr 2;360(14):1418-28. doi: 10.1056/NEJMsa0803563. Erratum In: N Engl J Med. 2011 Apr 21;364(16):1582.
- Krumholz HM. Post-hospital syndrome--an acquired, transient condition of generalized risk. N Engl J Med. 2013 Jan 10;368(2):100-2. doi: 10.1056/NEJMp1212324. No abstract available.
- Sanchis-Gomar F, Perez-Quilis C, Leischik R, Lucia A. Epidemiology of coronary heart disease and acute coronary syndrome. Ann Transl Med. 2016 Jul;4(13):256. doi: 10.21037/atm.2016.06.33.
- Leppin AL, Gionfriddo MR, Kessler M, Brito JP, Mair FS, Gallacher K, Wang Z, Erwin PJ, Sylvester T, Boehmer K, Ting HH, Murad MH, Shippee ND, Montori VM. Preventing 30-day hospital readmissions: a systematic review and meta-analysis of randomized trials. JAMA Intern Med. 2014 Jul;174(7):1095-107. doi: 10.1001/jamainternmed.2014.1608.
- Thakkar J, Kurup R, Laba TL, Santo K, Thiagalingam A, Rodgers A, Woodward M, Redfern J, Chow CK. Mobile Telephone Text Messaging for Medication Adherence in Chronic Disease: A Meta-analysis. JAMA Intern Med. 2016 Mar;176(3):340-9. doi: 10.1001/jamainternmed.2015.7667.
- Chow CK, Redfern J, Hillis GS, Thakkar J, Santo K, Hackett ML, Jan S, Graves N, de Keizer L, Barry T, Bompoint S, Stepien S, Whittaker R, Rodgers A, Thiagalingam A. Effect of Lifestyle-Focused Text Messaging on Risk Factor Modification in Patients With Coronary Heart Disease: A Randomized Clinical Trial. JAMA. 2015 Sep 22-29;314(12):1255-63. doi: 10.1001/jama.2015.10945. Erratum In: JAMA. 2016 Mar 8;315(10):1057.
- Adler AJ, Martin N, Mariani J, Tajer CD, Owolabi OO, Free C, Serrano NC, Casas JP, Perel P. Mobile phone text messaging to improve medication adherence in secondary prevention of cardiovascular disease. Cochrane Database Syst Rev. 2017 Apr 29;4(4):CD011851. doi: 10.1002/14651858.CD011851.pub2.
- 2022. "The TEACH (Texting After ACS Discharge) Pilot Randomized Trial". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05628337.
Frequently Asked Questions
Is this research endeavor currently recruiting participants?
"Indeed, the records hosted on clinicaltrials.gov show that this trial has been open for recruitment since June 16th 2022 and was recently adjusted on November 16th 2022. 250 individuals must be enrolled at just a single site in order to complete the study's objectives." - Anonymous Online Contributor
Unverified Answer
What is the enrollment capacity for this research endeavor?
"Affirmative. As documented on clinicaltrials.gov, this ongoing trial was first posted in mid-June and recently updated in mid-November 2022. The study requires 250 participants from one medical site to participate." - Anonymous Online Contributor
Unverified Answer