Cardiac MRI for Heart Failure
(STICOS Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to determine if heart tissue changes visible on MRI scans can predict serious issues like heart failure or hospital readmissions after procedures such as stents or bypass surgery. It focuses on patients with heart issues, specifically those with weakened heart pumping ability and significant artery blockages, who are scheduled for these procedures. The study targets individuals with a history of heart problems, reduced heart pumping ability, and plans for heart surgery or stenting within the next three months. As an unphased trial, this study offers participants the chance to contribute to important research that could enhance future heart care.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What prior data suggests that Cardiac Magnetic Resonance Imaging is safe for patients undergoing revascularization?
Research has shown that cardiac magnetic resonance imaging (MRI) is generally safe and well-tolerated. Many studies have found it to be a noninvasive method for detecting heart conditions, as it doesn't require surgery or entering the body.
Cardiac MRI accurately identifies heart issues without causing harm and is often used to diagnose heart diseases due to its ability to provide clear images. While any medical test can carry some risks, serious problems with cardiac MRI are rare.
Most individuals undergoing this imaging test report no major side effects. Occasionally, some may feel discomfort from lying still or from the contrast dye used during the test, but these effects are usually minor and short-lived. Overall, cardiac MRI is considered a safe option for those participating in heart studies.12345Why are researchers excited about this trial?
Most treatments for ischemic left ventricular systolic dysfunction (iLVSD) and coronary artery disease (CAD) focus on revascularization techniques like PCI (Percutaneous Coronary Intervention) or CABG (Coronary Artery Bypass Grafting). However, this study is unique because it uses cardiac magnetic resonance (CMR) imaging both before and potentially after these procedures. Researchers are excited because CMR offers a detailed look at the heart's structure and function, which could help tailor treatments to each patient's needs and improve outcomes. By collecting long-term clinical data, the study aims to provide insights into how these imaging techniques can enhance the effectiveness of existing revascularization methods.
What evidence suggests that cardiac magnetic resonance imaging is effective for predicting postoperative cardiovascular events?
Research has shown that Cardiac Magnetic Resonance Imaging (CMR) accurately diagnoses heart conditions. One study found that CMR correctly identified heart issues 86% to 89% of the time. Another study demonstrated that CMR can detect coronary artery disease (CAD) as effectively as more invasive methods. In this trial, patients diagnosed with ischemic left ventricular systolic dysfunction (iLVSD) and CAD undergoing revascularization may use CMR to assess heart function. CMR also evaluates blood flow through the heart and checks heart tissue health, helping to identify areas at risk. This non-invasive imaging method serves as a useful tool for predicting potential heart problems after procedures like stents or bypass surgery.34567
Who Is on the Research Team?
Mario Gaudino, MD, PhD, MSCE, FEBCTS, FACC
Principal Investigator
Weill Medical College of Cornell University
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Pre-procedure CMR
Eligible patients undergo preoperative Cardiac Magnetic Resonance Imaging (CMR) to assess heart tissue abnormalities
Revascularization Procedure
Participants undergo coronary revascularization via PCI or CABG
Postoperative CMR
Participants may undergo postoperative CMR to assess changes in heart tissue
Follow-up
Participants are monitored for long-term outcomes such as heart failure, readmission, or death
What Are the Treatments Tested in This Trial?
Interventions
- Cardiac Magnetic Resonance Imaging
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Eligible patients will be approached by study team before PCI or CABG for consent to participate in the study. For patients in whom the treating physicians have requested or will request pre-procedure CMR for clinical reasons, consent to collect long-term clinical data will be requested. Eligible patients who meet inclusion criteria in whom clinical CMR is not planned, will be asked to undergo preoperative CMR with or without postoperative CMR and to be followed up for research purposes.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Weill Medical College of Cornell University
Lead Sponsor
National Heart, Lung, and Blood Institute (NHLBI)
Collaborator
Citations
Cardiac Magnetic Resonance Imaging in Patients with ...
Because of its superior spatial resolution and endocardial border definition, this CMR method has been shown to yield higher diagnostic accuracy (86%; 89% ...
Advanced cardiac magnetic resonance imaging for ...
The ADVOCATE-CMR study aims to validate QP CMR, ∆T1 and OS-CMR imaging against invasive fractional flow reserve (FFR) for the detection of obstructive CAD.
Diagnostic accuracy of late gadolinium enhancement ...
This large, prospective multicentre study found that rest LGE-CMR has limited sensitivity (57%) for detecting significant CAD in patients with rLVEF, indicating ...
Stress Cardiac Magnetic Resonance Myocardial Perfusion ...
Stress cardiovascular magnetic resonance imaging (CMR) is a cost-effective, noninvasive test that accurately assesses myocardial ischemia, myocardial viability ...
Cardiac MRI in Front Line for the Diagnosis of Coronary ...
This analysis aims to enhance the diagnostic accuracy of coronary artery disease (CAD) detection in patients with reduced left ventricular ejection fraction ( ...
Cardiac Magnetic Resonance Imaging in Ischemic Heart ...
Cardiac magnetic resonance imaging (MRI) has emerged as a prime player in the clinical and preclinical detection of ischemic heart disease (IHD) as well in ...
Cardiac MRI in Front Line for the Diagnosis of Coronary ...
Theo Pezel, will apply advanced AI algorithms to detect ischemic patterns and quantify myocardial scarring. This AI analysis aims to improve the sensitivity and ...
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