Response Inhibition Training (RIT) for Obsessive-Compulsive Disorder

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Obsessive-Compulsive Disorder+2 MoreComputerized cognitive training - Behavioral
Eligibility
18 - 60
All Sexes
What conditions do you have?
Select

Study Summary

The impaired ability to suppress an inappropriate but pre-potent response (response inhibition; RI) characterizes several debilitating clinical problems, including obsessive-compulsive and related disorders (OCRD) such as obsessive-compulsive disorder, trichotillomania, and skin picking disorder. There is a critical need to develop an effective and durable treatment for OCRDs with demonstrable evidence for improving impaired RI. The purpose of our project is to examine the impact of a novel computerized intervention, response inhibition training (RIT), on neural indices of RI, and examine the mechanistic link between engagement of the neural RI targets and change in OCRD symptoms. To this end, this project will conduct a randomized clinical trial for individuals with OCD, trichotillomania, and/or skin picking disorders. Participants will be randomly assigned to 8 to 16 sessions of computerized RIT or a computerized placebo training. Various clinical, behavioral, and brain-imaging data will be acquired to evaluate the training effects at baseline, post-training, and 1-month follow-up periods.

Eligible Conditions
  • Obsessive-Compulsive Disorder
  • Tricholemmoma
  • Skin Picking Disorder

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

4 Primary · 1 Secondary · Reporting Duration: Week 0, Week 4, Week 8 ~ 12

Week 0, Week 4
Change in activation in the right inferior frontal cortex (rIFC)
Week 8
Change in compulsive hair pulling symptom severity over time
Change in compulsive skin picking symptom severity over time
Change in obsessive-compulsive disorder symptom severity over time
Change in the Clinical Global Impression Scale

Trial Safety

Safety Progress

1 of 3

Trial Design

2 Treatment Groups

Response Inhibition Training (RIT)
1 of 2
Placebo Training (PLT)
1 of 2

Experimental Treatment

Non-Treatment Group

118 Total Participants · 2 Treatment Groups

Primary Treatment: Response Inhibition Training (RIT) · Has Placebo Group · N/A

Response Inhibition Training (RIT)
Behavioral
Experimental Group · 1 Intervention: Computerized cognitive training · Intervention Types: Behavioral
Placebo Training (PLT)
Behavioral
PlaceboComparator Group · 1 Intervention: Computerized placebo training · Intervention Types: Behavioral
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Computerized cognitive training
2016
N/A
~480

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: week 0, week 4, week 8 ~ 12

Who is running the clinical trial?

University of Wisconsin, MilwaukeeLead Sponsor
46 Previous Clinical Trials
6,261 Total Patients Enrolled
2 Trials studying Obsessive-Compulsive Disorder
121 Patients Enrolled for Obsessive-Compulsive Disorder
Hanjoo Lee, Ph.D.Principal InvestigatorUniversity of Wisconsin, Milwaukee
1 Previous Clinical Trials
54 Total Patients Enrolled
Christine Larson, Ph.D.Principal InvestigatorUniversity of Wisconsin, Milwaukee

Eligibility Criteria

Age 18 - 60 · All Participants · 5 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You have a primary diagnosis of OCD, TTM, or SPD.

Who else is applying?

What state do they live in?
Michigan100.0%
What portion of applicants met pre-screening criteria?
Did not meet criteria100.0%
How many prior treatments have patients received?
0100.0%