Study Summary
This trial looks at how effective neoadjuvant therapy is in treating cancer, and whether adjuvant therapy after surgery can help prevent disease relapse.
- Metastatic Melanoma
- Melanoma Stage III
- BRAF V600E Mutation
Treatment Effectiveness
Phase-Based Effectiveness
Study Objectives
1 Primary · 5 Secondary · Reporting Duration: After surgery, up to 5 years
Trial Safety
Phase-Based Safety
Awards & Highlights
Trial Design
4 Treatment Groups
Surveillance
1 of 4
Encorafenib and Binimetinib after Pathologic Complete Response
1 of 4
Nivolumab after Non-Pathologic Complete Response
1 of 4
Encorafenib and Binimetinib after Non-Pathologic Complete Response
1 of 4
Active Control
Experimental Treatment
50 Total Participants · 4 Treatment Groups
Primary Treatment: Encorafenib Pill · No Placebo Group · Phase < 1
Trial Logistics
Trial Timeline
Who is running the clinical trial?
Eligibility Criteria
Age 18+ · All Participants · 0 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:Frequently Asked Questions
Has research been conducted beyond the scope of Encorafenib Pill?
"Currently, 767 trials are researching the efficacy of Encorafenib Pill. Of these examinations, 86 have progressed to Phase 3. The majority of studies for this medication take place in Cambridge, England; however, there are over 42 thousand locations running clinical tests on this pharmaceutical treatment." - Anonymous Online Contributor
Is this research endeavor in need of more participants?
"Affirmative. Clinicaltrials.gov reveals that this medical investigation, which was initially posted on May 24th 2021, is presently recruiting for 50 participants at one location. It has also been updated most recently on November 2nd 2022." - Anonymous Online Contributor
How does this research compare to other similar initiatives?
"Since 2011, researchers have been exploring the potential of Encorafenib Pill. Pfizer was responsible for leading the initial trial in 2011 with 183 participants; this led to a Phase 2 drug approval. Currently there are 767 studies active across 2574 cities and 51 countries investigating its effects." - Anonymous Online Contributor
To what extent is the current clinical trial being populated by participants?
"Affirmative. Per the clinicaltrials.gov website, recruitment for this trial is in progress. The study was published on May 24th 2021 and last modified on November 2nd 2022; 50 participants must be sourced from a single medical site." - Anonymous Online Contributor
To what ailments can Encorafenib Pill be administered to provide relief?
"Encorafenib Pill has been proven to be an effective management strategy for malignant neoplasms, unresectable melanoma and squamous cell carcinoma." - Anonymous Online Contributor