Utero-ovarian Transposition for Cancer-related Infertility
(UOT WPXRT Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests a new surgery called utero-ovarian transposition for women with pelvic cancers who wish to preserve fertility. The surgery relocates the uterus and ovaries to shield them during radiation treatment. Women needing radiation who want to maintain fertility may be suitable candidates. The study evaluates the procedure's safety and effectiveness by assessing recovery, menstrual health, and quality of life. As an unphased trial, it offers participants the opportunity to contribute to pioneering research that could improve fertility preservation options for future patients.
What prior data suggests that this technique is safe for preserving fertility in women undergoing pelvic radiation therapy?
Earlier research on uterine transposition, part of the utero-ovarian transposition (UOT) technique, has shown promising safety results. Initial findings suggest that this method effectively preserves ovarian function and menstrual cycles. Most patients returned to normal hormone levels and menstrual cycles after surgery, with some achieving successful pregnancies.
One study found that six patients underwent the procedure and maintained normal menstrual function and hormone levels afterward. Another study demonstrated that robotic assistance for uterine transposition was safe and effective in preserving fertility, particularly for patients requiring pelvic radiation.
Overall, these studies provide encouraging evidence that UOT is safe, can be performed with minimal complications, and helps maintain fertility in patients needing pelvic radiation.12345Why are researchers excited about this trial?
Uteroovarian transposition is unique because it offers a new way to preserve fertility in women undergoing radiotherapy for pelvic cancers. Unlike traditional fertility preservation methods that often involve complex hormonal treatments or egg freezing, this technique uses a minimally invasive surgical approach to relocate the ovaries away from radiation fields, reducing the risk of ovarian damage. Researchers are excited because this could improve reproductive outcomes and quality of life for women without requiring additional reproductive interventions, making it a game-changer in fertility preservation for cancer patients.
What evidence suggests that uterine and ovarian transposition is effective for preserving fertility in cancer-related infertility?
Research has shown that moving the ovaries (utero-ovarian transposition or UOT) can help women maintain fertility despite needing pelvic radiation therapy. This trial will evaluate UOT, which studies have shown to successfully protect ovarian function, with some reporting up to 100% success. Many women have resumed regular menstrual cycles, and some have become pregnant after the procedure. Clinical results also suggest that women can have successful pregnancies after surgery. These findings support UOT as a promising option for preserving fertility in women with pelvic cancers.16789
Who Is on the Research Team?
Vaagn Andikyan
Principal Investigator
USF Health Morsani College of Medicine
Are You a Good Fit for This Trial?
Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Surgery
Participants undergo utero-ovarian transposition (UOT) using a minimally invasive approach
Radiation Therapy
Whole pelvic external radiation therapy (WPXRT) is administered to treat pelvic malignancies
Follow-up
Participants are monitored for surgical outcomes, hormonal function, menstrual function, and quality of life
What Are the Treatments Tested in This Trial?
Interventions
- Uteroovarian Transposition
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Our study population includes premenopausal women 18-40 years old who are diagnosed with pelvic malignancies, such as rectal, colorectal cancer, and other pelvic malignancies that require radiotherapy and wish to preserve fertility and ovarian function. Subjects will be interested in improving their quality of life and reproductive outcomes without the need to undergo additional reproductive endocrinology interventions. Eligible patients will undergo UOT using a novel minimally invasive approach.
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of South Florida
Lead Sponsor
Citations
Uterine Transposition for Fertility Preservation and Ovarian ...
Early clinical outcomes have been promising, with high rates of ovarian function preservation, menstrual resumption, and successful pregnancies, ...
Utero-ovarian Transposition in Patients With Pelvic ...
This study will assess surgical outcomes for enrolled subjects undergoing this care plan, assess quality of life and the preservation of fertility and uterine ...
Ovarian transposition in patients with cervical cancer prior ...
Ovarian transposition prior to brachytherapy is associated with preservation of ovarian function in 83% to 100% (n=60/70) compared with 41.6% to 60% (n=23/42) ...
Ovarian Transposition and Uterine Fixation
outcomes of the two fertility preservation ... Use of Fertility Preservation Services in Female Reproductive-Aged Cancer Patients.
Fertility Assessment after Ovarian Transposition in Children ...
Recent studies highlighted that 38% women were able to conceive after ovarian tissue transplantation following gonadal tissue cryopreservation ...
Robotic uterine transposition for fertility preservation in a ...
Robotic UT may be a safe and effective fertility-preserving option for patients who need pelvic radiation. In this case, it allowed for uninterrupted cancer ...
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international-journal-of-gynecological-cancer.com
international-journal-of-gynecological-cancer.com/article/S1048-891X(24)01469-5/fulltextUterine transposition for fertility and ovarian function ...
The uterus was successfully preserved in six patients, accompanied by normal menses, hormonal levels, and vaginal intercourse after treatment. One patient with ...
Ovarian Transposition an Option for Fertility Preservation ...
Our cervical cancer survival rates exceed 1.5 times the national average, with the greatest improvement of outcomes seen among advanced-stage ...
Utero-ovarian transposition before pelvic radiation in a ...
UOT represents a valuable option to preserve fertility in patients requiring pelvic radiotherapy. This study provides additional evidence on the feasibility ...
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