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Colorectal Cancer (Training cohort) for Colorectal Cancer (AACRC Trial)

N/A
Recruiting
Led By Ajay Goel, PhD
Research Sponsored by City of Hope Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up through study completion, an average of 1 year
Awards & highlights

AACRC Trial Summary

This study aims to develop a highly sensitive, specific, and cost-effective blood assay for early detection of colorectal adenomas and cancer, using advanced machine learning and state-of-the-art biological analyses.

Eligible Conditions
  • Colorectal Cancer
  • Colorectal Adenomas
  • Colorectal Polyps
  • Colorectal Dysplasia
  • Liver metastases
  • Colon Cancer
  • Colon Polyps
  • Colorectal Disorders
  • Polyps

AACRC Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~through study completion, an average of 1 year
This trial's timeline: 3 weeks for screening, Varies for treatment, and through study completion, an average of 1 year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Sensitivity
Secondary outcome measures
Proportion of correct predictions (true positives and true negatives) among the total number of cases (i.e., accuracy)
Specificity

AACRC Trial Design

12Treatment groups
Experimental Treatment
Group I: Non-disease controls (Validation cohort)Experimental Treatment1 Intervention
Individuals who underwent colonoscopy and were found not to have any adenomas or cancer.
Group II: Non-disease controls (Training cohort)Experimental Treatment1 Intervention
Individuals who underwent colonoscopy and were found not to have any adenomas or cancer.
Group III: Non-disease controls (Discovery cohort)Experimental Treatment0 Interventions
Individuals who underwent colonoscopy and were found not to have any adenomas or cancer.
Group IV: Low-risk Adenoma (Validation cohort)Experimental Treatment1 Intervention
Individuals who underwent colonoscopy and were found to only have low-risk adenomas, defined as: 1 or 2 adenomas at most. All adenomas have low-grade dysplasia at most. All adenomas are <10 mm in diameter. All adenomas are tubular
Group V: Low-risk Adenoma (Training cohort)Experimental Treatment1 Intervention
Individuals who underwent colonoscopy and were found to only have low-risk adenomas, defined as: 1 or 2 adenomas at most. All adenomas have low-grade dysplasia at most. All adenomas are <10 mm in diameter. All adenomas are tubular
Group VI: Low-risk Adenoma (Discovery cohort)Experimental Treatment0 Interventions
Individuals who underwent colonoscopy and were found to only have low-risk adenomas, defined as all of the following: 1 or 2 adenomas at most. All adenomas have low-grade dysplasia at most. All adenomas are <10 mm in diameter. All adenomas are tubular
Group VII: Colorectal Cancer (Validation cohort)Experimental Treatment1 Intervention
Individuals who underwent colonoscopy and were found to have colorectal cancer.
Group VIII: Colorectal Cancer (Training cohort)Experimental Treatment1 Intervention
Individuals who underwent colonoscopy and were found to have colorectal cancer.
Group IX: Colorectal Cancer (Discovery cohort)Experimental Treatment0 Interventions
Individuals who underwent colonoscopy and were found to have colorectal cancer.
Group X: Advanced Adenoma (Validation cohort)Experimental Treatment1 Intervention
Individuals who underwent colonoscopy and were found to have high-risk adenomas, defined as one or more of the following: 3 or more adenomas. One or more adenomas have high-grade dysplasia. One or more adenomas are >10 mm in diameter. One or more adenomas are villous
Group XI: Advanced Adenoma (Training cohort)Experimental Treatment1 Intervention
Individuals who underwent colonoscopy and were found to have high-risk adenomas, defined as one or more of the following: 3 or more adenomas. One or more adenomas have high-grade dysplasia. One or more adenomas are >10 mm in diameter. One or more adenomas are villous
Group XII: Advanced Adenoma (Discovery cohort)Experimental Treatment0 Interventions
Individuals who underwent colonoscopy and were found to have high-risk adenomas, defined as one or more of the following: 3 or more adenomas. One or more adenomas have high-grade dysplasia. One or more adenomas are >10 mm in diameter. One or more adenomas are villous

Find a Location

Who is running the clinical trial?

City of Hope Medical CenterLead Sponsor
565 Previous Clinical Trials
1,919,460 Total Patients Enrolled
Ajay Goel, PhDPrincipal InvestigatorCity of Hope Medical Center
6 Previous Clinical Trials
2,377 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
Science Translational MedicineJournal
Detection of Circulating Tumor DNA in Early- and Late-stage Human Malignancies
Bettegowda, Chetan, Mark Sausen, Rebecca J. Leary, Isaac Kinde, Yuxuan Wang, Nishant Agrawal, Bjarne R. Bartlett, et al.. 2014. “Detection of Circulating Tumor DNA in Early- and Late-stage Human Malignancies”. Science Translational Medicine. American Association for the Advancement of Science (AAAS). doi:10.1126/scitranslmed.3007094.
clinicaltrials.govStudy
Early Detection of Advanced Adenomas and Colorectal Cancer
2020. "Early Detection of Advanced Adenomas and Colorectal Cancer". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06342440.
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