Pomegranate Juice for Ulcerative Colitis
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores whether drinking 237 ml of pomegranate juice daily can help individuals with ulcerative colitis (UC) by reducing inflammation and improving gut health. Researchers aim to determine if this juice can alter the gut's microbiota—tiny organisms living there—and enhance overall well-being. Participants will either begin by drinking the juice for eight weeks or wait and start later, maintaining their usual diet during the other period. The trial seeks individuals with mild-to-moderate UC who consume fewer than three servings of fruits and vegetables daily and have ongoing inflammation. As an unphased trial, this study offers a unique opportunity to contribute to understanding natural dietary interventions for UC.
Will I have to stop taking my current medications?
The trial requires that if you are on 5-aminosalicylates or immunosuppressive therapy, you must be on a stable dose for a certain period before starting the trial. If you are taking certain supplements or medications like cyclosporine, tacrolimus, or thalidomide, you may need to stop them before joining. Please check with the trial team for specific guidance on your medications.
Is there any evidence suggesting that pomegranate juice is safe for consumption?
Research has shown that pomegranate juice is generally safe for consumption. Studies suggest it might help reduce inflammation, potentially benefiting conditions like ulcerative colitis. In past trials, participants who drank pomegranate juice did not report major side effects and found it easy to tolerate.
Although the FDA has not approved pomegranate juice specifically for treating ulcerative colitis, its status as a common food product indicates it is generally safe to consume in normal amounts.
However, before making any new supplement or dietary change, consulting a healthcare provider is wise. They can ensure it is safe for individual health needs.12345Why are researchers excited about this trial?
Pomegranate juice is unique because it offers a natural alternative to traditional medications for ulcerative colitis, which typically include anti-inflammatory drugs and immune system suppressors. Unlike these medications, which can have significant side effects, pomegranate juice is rich in antioxidants and has an anti-inflammatory effect without the same risk profile. Researchers are excited about its potential to soothe inflammation and support gut health in a gentler and more holistic way. Additionally, pomegranate juice is easy to incorporate into a daily routine, making it a convenient option for patients seeking dietary-based interventions.
What evidence suggests that pomegranate juice might be an effective treatment for ulcerative colitis?
Research has shown that pomegranate juice might help reduce inflammation in people with ulcerative colitis. One study found that patients who drank pomegranate juice for 12 weeks experienced less intestinal inflammation. In this trial, participants in one arm will consume pomegranate juice for the first 8 weeks, while those in the other arm will begin consuming it after an initial 8-week period on their habitual diet. The juice is believed to be beneficial due to its antioxidants and anti-inflammatory substances. Pomegranate seed oil may also alleviate colitis symptoms similarly. Overall, early research suggests that pomegranate juice could be a promising natural option for reducing inflammation related to ulcerative colitis.12678
Who Is on the Research Team?
Zhaoping Li, MD, PhD
Principal Investigator
University of California, Los Angeles
Are You a Good Fit for This Trial?
This trial is for individuals with Ulcerative Colitis, a type of Inflammatory Bowel Disease. Participants should be currently following their habitual diet and are willing to consume pomegranate juice daily for the study period.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Phase 1 Treatment
Intervention group consumes 237 ml of pomegranate juice daily; delayed start group follows habitual diet
Phase 2 Treatment
Delayed start group consumes 237 ml of pomegranate juice daily; intervention group follows habitual diet
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Pomegranate Juice
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of California, Los Angeles
Lead Sponsor
National Institutes of Health (NIH)
Collaborator
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborator