Aspirin for Preeclampsia
Trial Summary
What is the purpose of this trial?
This is a single-center, double-blind, randomized, placebo-controlled clinical trial. Peripartum and postpartum Activin A are significantly elevated in women with preeclampsia. Our hypothesis is that elevated Activin A levels reflect a remediable signal and that reducing postpartum Activin A levels with aspirin therapy will improve (GLS) in preeclamptic patients.
Will I have to stop taking my current medications?
The trial requires that you do not take any nonsteroidal anti-inflammatory drugs (like ibuprofen) while participating. If you are currently taking these, you will need to stop.
What data supports the effectiveness of the drug aspirin in preventing preeclampsia?
Research shows that taking low-dose aspirin early in pregnancy can help reduce the risk of preeclampsia, a condition that can cause high blood pressure and other problems during pregnancy. Studies have found that aspirin is particularly effective for women at high risk of developing this condition.12345
Is low-dose aspirin safe for pregnant women?
How does aspirin differ from other drugs for preeclampsia?
Aspirin is unique for preeclampsia prevention because it is used in low doses and its effectiveness depends on the timing and dosage, with doses over 100 mg daily before 16 weeks of pregnancy being most effective. Unlike other treatments, aspirin is widely studied and recommended by various health organizations, but guidelines on its use vary significantly.611121314
Eligibility Criteria
This trial is for pregnant adults aged 18-45 diagnosed with preeclampsia and expecting one baby. It's not for those planning to deliver outside the study site, involved in other trials, or with conditions like ulcers, bleeding disorders, heart disease, diabetes, kidney issues or multiple pregnancies. Also excluded are those allergic to aspirin or needing NSAIDs.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants with elevated Activin A levels receive either aspirin therapy or placebo postpartum
Follow-up
Participants are monitored for safety and effectiveness after treatment, with measurements of GLS and other cardiac functions
Treatment Details
Interventions
- Aspirin
- Placebo
Aspirin is already approved in European Union, United States, Canada, China for the following indications:
- Pain relief
- Fever reduction
- Inflammation
- Cardiovascular disease prevention
- Preeclampsia prevention
- Pain relief
- Fever reduction
- Inflammation
- Cardiovascular disease prevention
- Preeclampsia prevention
- Pain relief
- Fever reduction
- Inflammation
- Cardiovascular disease prevention
- Preeclampsia prevention
- Pain relief
- Fever reduction
- Inflammation
- Cardiovascular disease prevention
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Chicago
Lead Sponsor