Brain Longevity Supplement for Cognitive Functioning

(CLARITY Trial)

Overseen By Study Manager

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: Amazentis SA

Must not be taking: Anticoagulants, Antidepressants, Antipsychotics, others

Disqualifiers: Pregnancy, Heavy drinking, Cardiac dysfunction, others

Compensation: Varies

Number of Visits: Unknown

Duration: 8 weeks

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests a new brain supplement, the Novel Brain Longevity Supplement, which might improve memory and thinking skills. Researchers will assess its effectiveness by comparing it to a placebo (a look-alike pill with no active ingredients). Participants will take either the supplement or placebo for 8 weeks and report changes in cognitive function through online surveys. Adults in the U.S. who believe they could improve their mental sharpness by 30% or more may be suitable for this study. As an unphased trial, this study offers a unique opportunity to contribute to groundbreaking research on cognitive enhancement.

Will I have to stop taking my current medications?

You may need to stop taking certain medications if they have a known interaction with the study product. This includes medications like anticoagulants, antidepressants, and others listed in the trial's exclusion criteria.

Is there any evidence suggesting that this treatment is likely to be safe for humans?

Research has shown that Urolithin A, a key component of the Novel Brain Longevity Supplement, is generally safe and well-tolerated. Studies with older adults have found no major side effects from Urolithin A, suggesting the supplement is likely safe. Its use in other health areas has also supported its safety profile. However, as with any new treatment, individual experiences may vary, so staying informed and consulting healthcare providers is important. ^{1 2 3 4 5}

Why do researchers think this study treatment might be promising?

Researchers are excited about the Novel Brain Longevity Supplement because it uses Mitopure Urolithin A, a groundbreaking ingredient targeting cognitive health. Unlike current treatments for cognitive decline, which often focus on neurotransmitter support or neuroprotection, this supplement aims to enhance mitochondrial function, potentially boosting brain energy and improving cognitive performance. This unique mechanism offers a fresh approach to brain health, sparking interest in its potential benefits.

What evidence suggests that this supplement might be an effective treatment for cognitive function?

This trial will compare the Novel Brain Longevity Supplement, containing Urolithin A, with a placebo. Research suggests that Urolithin A might improve memory and learning. Animal studies have shown that Urolithin A can enhance brain functions like learning and memory, particularly in aging and brain disease models. One study found that long-term use of Urolithin A improved various brain functions in mice with Alzheimer's disease. Additionally, it might support the immune system as people age, offering protection against inflammation related to aging. While these findings are promising, they primarily come from animal studies, and more research is needed to confirm these effects in humans. ^{1 3 6 7 8}

Who Is on the Research Team?

Susan Hewlings, PhD

Principal Investigator

Radicle Science Inc.

Are You a Good Fit for This Trial?

Adults in the USA concerned about cognitive functioning, brain fog, mental fatigue, or aging may qualify for this study. Participants will be randomly assigned to receive either a novel supplement with Urolithin A (Mitopure) or a placebo.

Inclusion Criteria

Participants must have the opportunity for at least 30% improvement in their primary health outcome.

Participants must express a willingness to take a study product and not know the product identity (active or placebo) until the end of the study.

I am at least 40 years old and understand my participation will involve sex-specific aspects.

Exclusion Criteria

Individuals reporting current enrollment in another clinical trial.

Individuals reporting being a heavy drinker (defined as drinking 3 or more alcoholic beverages per day).

Individuals unable to read and understand English.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive the study product (active or placebo) for 8 weeks and complete electronic surveys assessing cognitive function

8 weeks

Surveys delivered via SMS or email

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

• Novel Brain Longevity Supplement

Trial Overview

The trial is testing the impact of a new brain health supplement containing Urolithin A on cognitive function over an 8-week period. It's randomized and double-blind, meaning neither participants nor researchers know who gets the real product versus placebo.

How Is the Trial Designed?

Group I: Active Active Control 1 Intervention

Novel nutritional product (containing Mitopure Urolithin A) targeting improvements in cognitive health

Group II: Placebo Placebo Group 1 Intervention

Identical Placebo product

Who Is Running the Clinical Trial?

Amazentis SA

Lead Sponsor

Trials

21

Recruited

1,400+

Radicle Science (sponsor)

Collaborator

Citations

1.

clinicaltrials.gov

clinicaltrials.gov/study/NCT07060898

Impact of a Novel Brain Longevity Supplement Containing ...

Impact of a Novel Brain Longevity Supplement Containing the Postbiotic Urolithin A (Mitopure) on Cognitive Function and Related Health Outcomes (CLARITY).

2.

pmc.ncbi.nlm.nih.gov

pmc.ncbi.nlm.nih.gov/articles/PMC11180933/

Urolithin A improves Alzheimer's disease cognition and ...

Long‐term urolithin A (UA) treatment improved learning, memory, and olfactory function in Alzheimer's disease (AD) mice. UA restored lysosomal functions in part ...

3.

timeline.com

timeline.com/?srsltid=AfmBOoqrbrSZXkLZWJmMu4NUrUe8VJwYsimpCjKp60fnf967K0bubc__

Timeline: Mitopure® | #1 Doctor Recommended Urolithin A

Optimize your cellular health with Mitopure® by Timeline, the first and only Urolithin A supplement clinically-proven to target the root causes of aging.

4.

nutraingredients.com

nutraingredients.com/Article/2025/11/05/urolithin-a-may-counteract-age-related-immune-decline-and-inflammaging/

Urolithin A may counteract age-related immune decline ...

Daily supplementation with MitoPure urolithin A may help maintain immune function with age and protect against inflammaging, says data from ...

5.

mdpi.com

mdpi.com/2072-6643/15/18/3884

Urolithins: A Prospective Alternative against Brain Aging

Uros administration has been shown significantly improve cognition, learning, and memory in aged animals and animal models of neurodegenerative diseases. It has ...

6.

trialx.com

trialx.com/clinical-trials/listings/306248/impact-of-a-novel-brain-longevity-supplement-containing-the-postbiotic-urolithin-a-mitopure-on-cognitive-function-and-related-health-outcomes/

Impact of a Novel Brain Longevity Supplement Containing ...

This is a parallel group, randomized, double-blind, placebo-controlled clinical study assessing the safety and effects of a novel nutritional ...

7.

longevity.technology

longevity.technology/clinics/urolithin-a-benefits-side-effects-dosage-foods-precautions/

Urolithin A: Benefits, Side Effects, Dosage, Foods, ...

Based on the available clinical trial data, Urolithin A appears to be safe and well-tolerated in older adults, with no significant side effects ...

8.

timeline.com

timeline.com/?srsltid=AfmBOoqVjvL3XW-d6Q3g5v1jrWoKFl1xhNNLCj3k3n229U_6l5L-2jXb

Timeline: Mitopure® | #1 Doctor Recommended Urolithin A

Optimize your cellular health with Mitopure® by Timeline, the first and only Urolithin A supplement clinically-proven to target the root causes of aging.