Brain Training for Mild Cognitive Impairment
Trial Summary
What is the purpose of this trial?
This study will train a machine learning tool to predict response to a cognitive training intervention using baseline brain MRI sequences from older adults with amnestic mild cognitive impairment.
Will I have to stop taking my current medications?
The trial does not specify if you must stop taking your current medications, but you cannot use antipsychotics, sedatives, or medications with significant anticholinergic properties. Also, you should not use photo-sensitive medications like steroids or retin-A within 15 days of the study.
What data supports the effectiveness of the treatment TRAIN, Cognitive Training Intervention, Machine Learning Tool for Cognitive Training for Mild Cognitive Impairment?
Research shows that cognitive training can help maintain or slightly improve memory in people with mild cognitive impairment (MCI), especially in those with certain biological traits like a larger left entorhinal cortex. Additionally, cognitive training has been shown to improve verbal memory and increase brain activity in areas related to memory, suggesting it can be beneficial for people with MCI.12345
Is brain training for mild cognitive impairment safe for humans?
The studies suggest that brain training for mild cognitive impairment is generally safe for humans, as participants in various trials, including those with mild cognitive impairment, completed the training without significant safety concerns. However, more research is needed to confirm these findings across larger and more diverse groups.16789
How does brain training differ from other treatments for mild cognitive impairment?
Brain training for mild cognitive impairment is unique because it uses computer-based exercises to improve cognitive abilities by enhancing brain plasticity (the brain's ability to change and adapt). Unlike medications, which have generally not been successful for this condition, brain training targets specific cognitive skills and neural networks to potentially improve overall cognitive function.410111213
Research Team
Joseph M Gullett, PhD
Principal Investigator
University of Florida
Eligibility Criteria
This trial is for older adults with mild cognitive impairment who have a close informant to report on their cognition, can handle daily activities despite some difficulties, and score within normal limits on a cognitive screening. They must not be dependent on certain medications or have conditions like dementia, major psychiatric disturbances, uncontrolled medical issues, or past participation in similar studies.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Baseline Assessment
Baseline brain MRI sequences and neuropsychological assessments are conducted
Treatment
Participants undergo cognitive training using the Posit Science Brain HQ Suite for 16 weeks
Follow-up
Participants are monitored for cognitive improvements and changes in UFOV composite score
Treatment Details
Interventions
- TRAIN
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Florida
Lead Sponsor
National Institute on Aging (NIA)
Collaborator