Brain Stimulation for Cognitive Impairment

Overseen By Ishita Basu, PhD

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: University of Cincinnati

Disqualifiers: Cognitive impairments, Physical impairments, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Approved in 2 Jurisdictions This treatment is already approved in other countries

Compensation: Varies

Number of Visits: Unknown

5 Participants Needed

Trial Summary

What is the purpose of this trial?

This is a basic neuroscience study of modulating brain oscillations involved in cognitive control. We will record brain signals and stimulate specific regions of the brain in human participants who are undergoing monitoring for epilepsy surgery. It is not a clinical trial for treating any disease.

Eligibility Criteria

This study is for adult patients at the University of Cincinnati Medical Center who are already getting EEG monitoring for epilepsy treatment and can consent to participate. It excludes minors, those with cognitive or physical impairments affecting test participation, non-English speakers, pregnant women, and prisoners.

Inclusion Criteria

I am an adult with drug-resistant epilepsy and am getting EEG monitoring at the University of Cincinnati Medical Center.

Exclusion Criteria

I am unable to give consent for medical procedures.

I do not speak English.

Pregnant women (note: pregnant women are not candidates for intracranial EEG monitoring)

Treatment Details

Interventions

• Brain Stimulation

Trial Overview The study involves brain stimulation while recording EEG in participants. It aims to understand how stimulating certain brain areas affects cognitive control but isn't designed as a treatment trial for any condition.

Participant Groups

Group I: Electrical stimulation Experimental Treatment 1 Intervention

Participants will receive brief electrical brain stimulation as they perform the study tasks. This will be linked to events occurring on screen and/or to specific changes in their brain activity. The stimulation parameters will be individualized for each participant, but will never exceed safe limits for charge density (30 µC/phase). They will always be tested beforehand to ensure that they do not cause participants any discomfort or distress.

Who Is Running the Clinical Trial?

University of Cincinnati

Lead Sponsor

Trials

442

Recruited

639,000+