690 Participants Needed

Optical Coherence Tomography for Cataract

(OCT IOL Trial)

HM
DR
Overseen ByDenny Romfh, OD
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Oregon Health and Science University
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial examines how a new imaging method, optical coherence tomography (OCT), can improve cataract surgery for individuals who have previously undergone laser vision correction. The focus is on using OCT to measure the cornea's shape more precisely, aiding doctors in selecting the correct lens power to minimize vision issues post-surgery. It is particularly suitable for those who have had laser eye procedures like LASIK and require cataract surgery with a standard lens.

As an unphased trial, this study provides a unique opportunity to contribute to innovative research that could enhance surgical outcomes for future patients.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

What prior data suggests that this method is safe for guiding cataract surgery?

Studies have shown that cataract surgery is generally safe. Most patients do not experience serious problems. Possible risks include eye infection or swelling, but these are uncommon and usually treatable. Research indicates that serious issues affecting vision are rare. Cataract surgery ranks among the most common and safest procedures in the U.S.12345

Why are researchers excited about this trial?

Researchers are excited about this trial because it explores a new way to calculate the power of intraocular lenses for cataract surgery using Optical Coherence Tomography (OCT). Unlike traditional methods that rely on pre-surgery measurements and estimates that can be less accurate for patients who have had laser refractive surgery, this technique aims to provide more precise results by directly assessing eye structures with OCT. By enhancing accuracy, this approach could lead to better visual outcomes for patients, making it a promising advancement in cataract surgery care.

What evidence suggests that this OCT method is effective for guiding cataract surgery?

Research has shown that cataract surgery is highly effective. One study found that 74% to 98% of patients achieve 20/40 vision or better after the surgery, allowing most to drive without glasses. Another report indicated that 77.6% of patients experience clear vision post-procedure. Complications are rare, with over 98% of surgeries proceeding smoothly. Overall, cataract surgery is a proven method to enhance vision.678910

Who Is on the Research Team?

DH

David Huang, MD, PhD

Principal Investigator

Casey Eye Institute, Oregon Health & Science University

Are You a Good Fit for This Trial?

Inclusion Criteria

The subjects will be patients seeking cataract surgery with implantation of monofocal IOLs (including toric IOLs) but not multifocal or accommodative IOLs.
Subjects will have had post-laser vision correction (LVC) such as previous LASIK, PRK, laser sub-epithelial keratectomy (LASEK), epi-LASIK (surface laser ablation under a microkeratome-created epithelial flap) or RK. The post-LVC group will be subdivided into those who have previous hyperopic LVC and those who have previous myopic LVC.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants undergo cataract surgery with IOL implantation guided by OCT imaging

Up to 6 months
Baseline visit for IOL power prediction

Follow-up

Participants are monitored for accuracy of IOL power prediction and refractive outcomes

6 months
Post-operative visit no later than 6 months following surgery

What Are the Treatments Tested in This Trial?

Interventions

  • Cataract Surgery
  • Optical Coherence Tomography

Find a Clinic Near You

Who Is Running the Clinical Trial?

Oregon Health and Science University

Lead Sponsor

Trials
1,024
Recruited
7,420,000+

National Eye Institute (NEI)

Collaborator

Trials
572
Recruited
1,320,000+

Citations

The future of cataract surgery - PMC

Cataract surgery (CS) is one of the most cost-effective and commonest surgeries undertaken [1] with approximately 3.8 million performed annually ...

Cataract Surgery Patient Outcomes | John A. Moran Eye ...

Data collected in 2024 shows that intraoperative complications were rare, occurring in only 56 of 4,919 cataract surgeries (98.86% complications-free) ...

Assessing Resident Cataract Surgical Outcomes Using ...

VA outcomes after resident-performed cataract surgery vary from 74% to 98% achieving 20/40 vision or better.

Real-world visual outcomes of cataract surgery based on ...

Of the 773 (1333 eyes) patients who received cataract surgery, 77.6% achieved postoperative PVA ≥6/12 (0.5), 19.7% with PVA between 6/60 (0.1) and 6/12 (0.5) ...

Why Real-World Data is Key to Helping Advance Cataract ...

With data on more than 9 million patients and an average follow-up of nearly four years, this dataset provides clinicians and life sciences ...

Cataract Surgery: Risks, Recovery, Costs

What Are the Risks of Cataract Surgery? · Eye infection. · Bleeding in the eye. · Ongoing swelling of the front of the eye or inside of the eye.

Serious Adverse Events After Cataract Surgery - PMC

Cataract surgery continues to be a very safe surgical procedure with few patients experiencing serious sight-threatening adverse events.

Cataract surgery

Complications after cataract surgery are uncommon, and most can be treated successfully. Cataract surgery risks include: Swelling. Infection.

PATIENT SAFETY IN CATARACT SURGERY

Why focus on cataract surgery? Cataract surgery is the most common operation in the U.S. and among the safest procedures in medicine.

Patient Harm in Cataract Surgery: A Series of Adverse...

Massachusetts state agencies received reports of 37 adverse events (AEs) involving cataract surgery from 2011 to 2015. Fifteen were anesthesia related, ...