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Hyperpolarized Helium MRI for COPD Tracking

N/A

Recruiting

Led By Grace E Parraga, PhD

Research Sponsored by Dr. Grace Parraga

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Subject is ambulatory and can perform the 6MWT

Subject must be able to perform a breathhold for 16s

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 3 years

Awards & highlights

Study Summary

This trial is to develop imaging tools to track COPD and Bronchiectasis patients over time.

Who is the study for?

This trial is for men and women aged 50-85 with COPD, Bronchiectasis, or a significant smoking history (≥10 pack/years). Participants must be able to hold their breath for 16 seconds, walk on their own, perform specific lung function tests successfully, and have certain levels of lung capacity. Pregnant individuals or those with metal implants that can't be removed are excluded.Check my eligibility

What is being tested?

The study involves using advanced MRI techniques with Helium-3 and Xenon-129 to image the lungs. It aims to develop tools for better understanding the changes in the lungs over time due to COPD or Bronchiectasis by comparing CT scans and MRIs.See study design

What are the potential side effects?

While not explicitly listed in the provided information, typical side effects from MRI procedures may include discomfort from lying still during imaging, loud noises during scanning which might require ear protection, and potential feelings of claustrophobia.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I can walk on my own and can do a 6-minute walk test.

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I can hold my breath for 16 seconds.

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I am between 50-85 years old and have COPD, Bronchiectasis, or a smoking history of more than 10 pack-years.

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I can perform consistent lung function tests.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 3 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~3 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and 3 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Apparent Diffusion Coefficients (ADC)

Ventilation Defect Percent (VDP)

Secondary outcome measures

Six Minute Walk Distance (6MWD)

Spirometry

St. George's Respiratory Questionnaire (SGRQ)

Trial Design

1Treatment groups

Experimental Treatment

Group I: COPD and Bronchiectasis PatientsExperimental Treatment1 Intervention

All enrolled COPD and Bronchiectasis patients will undergo Pulmonary Function Tests, Hyperpolarized Helium MRI, chest CT, 6-Minute Walk Test, and complete questionnaires at up to 8 visits over 2-3 years.

0 / 4Eligibility criteria met

Find a Location

Who is running the clinical trial?

Dr. Grace ParragaLead Sponsor

5 Previous Clinical Trials

285 Total Patients Enrolled

London Health Sciences CentreOTHER

143 Previous Clinical Trials

49,758 Total Patients Enrolled

1 Trials studying Bronchiectasis

32 Patients Enrolled for Bronchiectasis

Grace E Parraga, PhDPrincipal InvestigatorRobarts Research Institute, The University of Western Ontario

14 Previous Clinical Trials

1,164 Total Patients Enrolled

1 Trials studying Bronchiectasis

32 Patients Enrolled for Bronchiectasis

Media Library

COPD and Bronchiectasis Patients Clinical Trial Eligibility Overview. Trial Name: NCT02279329 — N/A

Bronchiectasis Research Study Groups: COPD and Bronchiectasis Patients

Bronchiectasis Clinical Trial 2023: COPD and Bronchiectasis Patients Highlights & Side Effects. Trial Name: NCT02279329 — N/A

COPD and Bronchiectasis Patients 2023 Treatment Timeline for Medical Study. Trial Name: NCT02279329 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Am I a suitable candidate for this research project?

"This clinical trial requires that applicants have bronchiectasis and are aged between 50-85. The research team is currently seeking 200 participants for the study."

Answered by AI

Are there any current opportunities for enrollment in this trial?

"Affirmative. Per the clinicaltrials.gov website, this trial is currently soliciting volunteers - it was initially posted on May 1st 2009 and last updated in 10th of May 2023. The aim is to gather 200 participants from two distinct sites."

Answered by AI

Are those 45 years of age or younger eligible for this research endeavor?

"Patients aged 50-85 are the only individuals eligible for this clinical trial. However, there are 13 trials available for minors and 301 studies open to geriatric patients."

Answered by AI

How many participants have been enrolled in this clinical trial thus far?

"Affirmative. According to clinicaltrials.gov, this clinical trial started recruiting on May 1st 2009 and remains active today with its most recent edit made on May 10th 2023. It requires a total of 200 participants from 2 sites for completion."

Answered by AI

Recent research and studies

RadiologyJournal

Pulmonary Ventilation Maps Generated with Free-breathing Proton MRI and a Deep Convolutional Neural Network

Capaldi, Dante P. I., Fumin Guo, Lei Xing, and Grace Parraga. 2021. “Pulmonary Ventilation Maps Generated with Free-breathing Proton MRI and a Deep Convolutional Neural Network”. Radiology. Radiological Society of North America (RSNA). doi:10.1148/radiol.2020202861.

clinicaltrials.govStudy

Longitudinal Study of Helium-3 and Xenon-129 Magnetic Resonance Imaging

Dr. Grace Parraga 2009. "Longitudinal Study of Helium-3 and Xenon-129 Magnetic Resonance Imaging". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02279329.

All > Bronchiectasis > Copd