Increased Water Intake for Blood Sugar Regulation

Age: 18 - 65

Sex: Any

Trial Phase: Academic

Sponsor: California Polytechnic State University-San Luis Obispo

Must not be taking: Oral contraceptives

Disqualifiers: Diabetes, Pre-diabetes, Pregnancy, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 2

20 Participants Needed

What You Need to Know Before You Apply

What is the purpose of this trial?

This clinical trial aims to learn if increasing water intake for five days can lower blood glucose in healthy, free-living individuals. The main question it aims to answer is whether increasing water intake will reduce daily blood glucose. Researchers will compare blood glucose when drinking adequate water to when the same individuals drink a low amount of water to see if blood glucose differs with water intake. Participants will be asked to drink a prescribed volume of water over two weeks while wearing a continuous glucose monitor and collecting two urine voids throughout each day.

Will I have to stop taking my current medications?

The trial does not specify if you need to stop taking your current medications, but it does exclude those taking oral contraceptives.

Is increased water intake generally safe for humans?

Research suggests that increasing water intake is generally safe for humans and may help regulate blood sugar levels, especially in those with diabetes. Proper hydration is important for overall health and can reduce the risk of developing chronic diseases. ^{1 2 3 4 5}

How does increased water intake help regulate blood sugar differently from other treatments?

Increased water intake is unique because it helps regulate blood sugar by potentially lowering levels of copeptin, a marker linked to vasopressin, which is associated with diabetes risk. Unlike medications that directly target blood sugar levels, this approach may work by influencing hormonal pathways related to hydration and stress response. ^{1 2 6 7 8}

What data supports the effectiveness of the treatment Water Intake for blood sugar regulation?

Some studies suggest that increasing water intake may help improve blood sugar levels, especially when water replaces sugary or calorie-laden drinks. Additionally, certain mineral waters containing bicarbonate and magnesium might have a positive effect on blood sugar control. ^{1 7 8 9 10}

Who Is on the Research Team?

Adam D Seal, Ph.D.

Principal Investigator

California Polytechnic State University-San Luis Obispo

Are You a Good Fit for This Trial?

This trial is for healthy individuals aged 18-55 who can consent to participate. It's not suitable for those with diabetes, pre-diabetes, pregnancy, chronic illnesses, past digestive tract surgery or those taking oral contraceptives.

Inclusion Criteria

Able to provide written and verbal consent

Exclusion Criteria

I have diabetes.

I have never had surgery on my digestive system.

I have been diagnosed with pre-diabetes.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

1 visit (in-person)

First Intervention

Participants consume either high or low water intake for six days while wearing a continuous glucose monitor and collecting urine samples.

6 days

1 visit (in-person) to start, urine sample drop-off every other day

Washout

Participants consume fluids ad libitum for four days.

4 days

Second Intervention

Participants switch to the opposite water intake regimen for another six days.

6 days

Urine sample drop-off every other day

Follow-up

Participants are monitored for safety and effectiveness after treatment

1-2 weeks

What Are the Treatments Tested in This Trial?

Interventions

• Water Intake

Trial Overview The study investigates if drinking more water over five days can lower blood sugar levels in healthy people. Participants will monitor their blood glucose continuously and compare the effects of normal versus low water intake on their blood sugar.

How Is the Trial Designed?

Group I: High water intake Experimental Treatment 1 Intervention

For six days, participants will consume the NAM's recommended total water intake of 2.7 liters per day for women and 3.7 liters per day for men

Group II: Low water intake Active Control 1 Intervention

For six days, participants will consume 0.7 liters per day for women and 1 liter per day for men.

Who Is Running the Clinical Trial?

California Polytechnic State University-San Luis Obispo

Lead Sponsor

Trials

33

Recruited

3,400+

Citations

1. United States pubmed.ncbi.nlm.nih.gov

Challenges of linking chronic dehydration and fluid consumption to health outcomes. [2015]

2. Switzerland pubmed.ncbi.nlm.nih.gov

Prevention and Therapy of Type 2 Diabetes-What Is the Potential of Daily Water Intake and Its Mineral Nutrients? [2022]

3. Netherlands pubmed.ncbi.nlm.nih.gov

Water intake and risk of type 2 diabetes: A systematic review and meta-analysis of observational studies. [2021]

4. United States pubmed.ncbi.nlm.nih.gov

Effect of Salt Supplementation on Sympathetic Activity and Endothelial Function in Salt-Sensitive Type 2 Diabetes. [2021]

5. United States pubmed.ncbi.nlm.nih.gov

Water Supplementation Reduces Copeptin and Plasma Glucose in Adults With High Copeptin: The H2O Metabolism Pilot Study. [2020]

6. United States pubmed.ncbi.nlm.nih.gov

Reduced water intake deteriorates glucose regulation in patients with type 2 diabetes. [2018]

7. United States pubmed.ncbi.nlm.nih.gov

Low water intake and risk for new-onset hyperglycemia. [2021]

8. Switzerland pubmed.ncbi.nlm.nih.gov

Current Hydration Habits: The Disregarded Factor for the Development of Renal and Cardiometabolic Diseases. [2023]

9. United States pubmed.ncbi.nlm.nih.gov

Water Intake and Markers of Hydration Are Related to Cardiometabolic Risk Biomarkers in Community-Dwelling Older Adults: A Cross-Sectional Analysis. [2023]

10. England pubmed.ncbi.nlm.nih.gov

Investigation of possible underlying mechanisms behind water-induced glucose reduction in adults with high copeptin. [2022]