Increased Water Intake for Blood Sugar Regulation

Age: 18 - 65

Sex: Any

Trial Phase: Academic

Sponsor: California Polytechnic State University-San Luis Obispo

Must not be taking: Oral contraceptives

Disqualifiers: Diabetes, Pre-diabetes, Pregnancy, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 2

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores whether increased water intake can help control blood sugar levels in healthy individuals. The researchers aim to determine if drinking more water results in lower blood glucose compared to drinking less. Participants will consume specific amounts of water while wearing a device that monitors their blood sugar. This study suits those who are healthy, do not have diabetes, and have not undergone digestive surgery. As an unphased trial, participants can contribute to foundational research that may influence future health recommendations.

Will I have to stop taking my current medications?

The trial does not specify if you need to stop taking your current medications, but it does exclude those taking oral contraceptives.

What prior data suggests that increased water intake is safe for blood sugar regulation?

Past studies have linked drinking a lot of water to better control of blood sugar levels. Research shows that increasing water intake can lower blood sugar by preventing dehydration and helping the body eliminate excess sugar through urine. One study found that drinking plenty of water reduced the risk of developing type 2 diabetes.

Importantly, the study suggested drinking 2.7 liters per day for women and 3.7 liters for men, and this amount has not been linked to any serious side effects in healthy individuals. Thus, consuming water at these levels is considered safe and manageable. ^{1 2 3 4 5}

Why are researchers excited about this trial?

Researchers are excited about increasing water intake for blood sugar regulation because it offers a natural and straightforward approach compared to standard treatments like medications or insulin therapy. Unlike these common methods, which often involve drugs or injections, this approach leverages the body's natural hydration processes, aiming to improve blood sugar levels by simply adjusting daily water consumption. This method could potentially offer a low-cost, non-invasive alternative with minimal side effects, making it an attractive option for individuals seeking lifestyle changes to manage their blood sugar levels.

What evidence suggests that increased water intake might be an effective treatment for blood glucose regulation?

This trial will compare the effects of high water intake with low water intake on blood sugar regulation. Research has shown that increased water consumption is linked to better blood sugar control. One study found that staying well-hydrated can increase blood fluid volume, potentially lowering blood sugar. Drinking water also helps remove excess sugar through urine, preventing dehydration. Evidence suggests that people who drink more water tend to manage their blood sugar more effectively. Some studies even show that replacing sugary drinks with water can improve blood sugar levels. Overall, these findings suggest that drinking more water could help regulate blood sugar. ^{1 2 4 5 6}

Who Is on the Research Team?

Adam D Seal, Ph.D.

Principal Investigator

California Polytechnic State University-San Luis Obispo

Are You a Good Fit for This Trial?

This trial is for healthy individuals aged 18-55 who can consent to participate. It's not suitable for those with diabetes, pre-diabetes, pregnancy, chronic illnesses, past digestive tract surgery or those taking oral contraceptives.

Inclusion Criteria

Able to provide written and verbal consent

Exclusion Criteria

I have diabetes.

I have never had surgery on my digestive system.

I have been diagnosed with pre-diabetes.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

1 visit (in-person)

First Intervention

Participants consume either high or low water intake for six days while wearing a continuous glucose monitor and collecting urine samples.

6 days

1 visit (in-person) to start, urine sample drop-off every other day

Washout

Participants consume fluids ad libitum for four days.

4 days

Second Intervention

Participants switch to the opposite water intake regimen for another six days.

6 days

Urine sample drop-off every other day

Follow-up

Participants are monitored for safety and effectiveness after treatment

1-2 weeks

What Are the Treatments Tested in This Trial?

Interventions

• Water Intake

Trial Overview The study investigates if drinking more water over five days can lower blood sugar levels in healthy people. Participants will monitor their blood glucose continuously and compare the effects of normal versus low water intake on their blood sugar.

How Is the Trial Designed?

Group I: High water intake Experimental Treatment 1 Intervention

For six days, participants will consume the NAM's recommended total water intake of 2.7 liters per day for women and 3.7 liters per day for men

Group II: Low water intake Active Control 1 Intervention

For six days, participants will consume 0.7 liters per day for women and 1 liter per day for men.

Who Is Running the Clinical Trial?

California Polytechnic State University-San Luis Obispo

Lead Sponsor

Trials

33

Recruited

3,400+

Citations

1. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC5197923/

An investigation into the relationship between plain water ... Having an improved hydration status increases plasma volume, which could reduce the concentration of blood glucose( ). Finally, hydration status directly ...

2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC6541888/

Water Supplementation Reduces Copeptin and Plasma ... Epidemiological evidence has shown that high water intake is associated with better glucose control (27), and rats with water-induced reduction in ...

3. signos.com signos.com/blog/water-lower-blood-sugar

Does Drinking Water Lower Blood Sugar? The Truth Unraveled The quick answer is yes, drinking water may help lower blood sugar. Water prevents dehydration and helps flush out excess sugar through your urine.

4. withpower.com withpower.com/trial/phase-blood-glucose-concentration-9-2024-ad9b7

Increased Water Intake for Blood Sugar Regulation Some studies suggest that increasing water intake may help improve blood sugar levels, especially when water replaces sugary or calorie-laden drinks.

5. diabetes.org diabetes.org/newsroom/press-releases/water-instead-diet-drinks-associated-two-fold-rate-diabetes-remission-women

Water Instead of Diet Drinks Associated with Two-Fold ... Notably, 90% of participants in the water group achieved diabetes remission, compared to 45% in the diet beverage group (P<0.0001). Additional ...

6. sciencedirect.com sciencedirect.com/science/article/abs/pii/S1871402121001673

Review Water intake and risk of type 2 diabetes There was an inverse relationship between water intake and risk of and type 2 diabetes. •. Drinking plain water resulted in 6% reduced risk in type 2 diabetes.