Biomarker Validation for ALS

Not currently recruiting at 2 trial locations
AC
MB
Overseen ByMichael Benatar, MBChB, MS, DPhil
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: University of Miami
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to develop treatments for ALS, a disease affecting nerve cells in the brain and spinal cord, and similar disorders. The researchers aim to test fluids like blood to identify biological markers that could facilitate the creation of new therapies. Individuals with ALS or related disorders, as well as healthy individuals without these diseases, can participate. Those diagnosed with ALS or a related condition, or those who are healthy with no risk of developing these disorders, might be suitable for this trial. Participants must be able and willing to follow study procedures. As an unphased trial, this study provides a unique opportunity to contribute to groundbreaking research that could lead to new treatments for ALS and similar disorders.

Why are researchers excited about this trial?

Researchers are excited about this trial because it aims to improve clinical trial readiness, which could streamline the process of bringing new therapies to patients faster. By refining protocols and methods, the trial seeks to address common bottlenecks in clinical research, such as patient recruitment and data collection. This effort could lead to more efficient trials, ultimately accelerating the development of innovative treatments for various conditions.

Who Is on the Research Team?

MB

Michael Benatar

Principal Investigator

University of Miami

Are You a Good Fit for This Trial?

Inclusion Criteria

Individuals with a clinical diagnosis of ALS or a related disorder, including FTD, ALS-FTD, PLS, and PMA.
Individuals never diagnosed with and not at particular risk of developing ALS or a related disorder.
Able and willing to comply with relevant procedures.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Biomarker Evaluation

Participants undergo evaluation of biological-fluid-based biomarker candidates for ALS and related disorders

12 months
Regular visits for sample collection

Follow-up

Participants are monitored for safety and effectiveness after biomarker evaluation

4 weeks

What Are the Treatments Tested in This Trial?

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Miami

Lead Sponsor

Trials
976
Recruited
423,000+

National Institutes of Health (NIH)

Collaborator

Trials
2,896
Recruited
8,053,000+

National Institute of Neurological Disorders and Stroke (NINDS)

Collaborator

Trials
1,403
Recruited
655,000+
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