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Adaptive Naming Treatment Schedules for Aphasia
Phase 2
Recruiting
Led By William Evans, PhD
Research Sponsored by University of Pittsburgh
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up initial assessment (pre-treatment), multiple timepoints up to 6-months post-treatment.
Awards & highlights
Study Summary
This trial evaluates novel treatments to help people with aphasia (language disorder) improve their ability to find words, with a focus on long-term retention and use in everyday life.
Who is the study for?
This trial is for people who have had a stroke leading to aphasia, a language disorder, and struggle with finding words. They must be at least six months post-stroke, show specific difficulties on the Comprehensive Aphasia Test, and can use telehealth services via high-speed internet. It's not for those with other neurological diseases, severe comprehension issues, uncontrolled substance dependence or serious mood disorders.Check my eligibility
What is being tested?
The study tests three different ways of scheduling picture-based naming exercises to help improve long-term word recall and usage in daily life for individuals with aphasia. Participants will try adaptive spacing (adjusting intervals based on performance), or one of two fixed schedules with varying amounts of practice items.See study design
What are the potential side effects?
Since this trial involves non-medical interventions like speech therapy exercises conducted through telehealth sessions, there are no direct physical side effects expected from participating in the treatments being tested.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ initial assessment (pre-treatment), multiple timepoints up to 6-months post-treatment.
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~initial assessment (pre-treatment), multiple timepoints up to 6-months post-treatment.
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Change in correct responses in Confrontation Naming of Treated and Untreated Pictured Objects
Change in correct responses in Context Generalization of Treated and Untreated Pictured Objects
Secondary outcome measures
Change in core lexicon analysis on the Aphasia Bank Discourse Protocol
Change in mean scores on the Aphasia Communication Outcome Measure Short-Form
Mean score on the Cactus and Camels Test (CCT)
+4 moreTrial Design
6Treatment groups
Experimental Treatment
Group I: Low-item non-adaptive spacing, then high-item non-adaptive spacing, then adaptive spacingExperimental Treatment3 Interventions
All participants will receive all three naming treatment conditions in a randomized order - this is one possible ordering of those conditions.
Group II: Low-item non-adaptive spacing, then adaptive spacing, then high-item non-adaptive spacingExperimental Treatment3 Interventions
All participants will receive all three naming treatment conditions in a randomized order - this is one possible ordering of those conditions.
Group III: High-item non-adaptive spacing, then low-item non-adaptive spacing, then adaptive spacingExperimental Treatment3 Interventions
All participants will receive all three naming treatment conditions in a randomized order - this is one possible ordering of those conditions.
Group IV: High-item non-adaptive spacing, then adaptive spacing, then low-item non-adaptive spacingExperimental Treatment3 Interventions
All participants will receive all three naming treatment conditions in a randomized order - this is one possible ordering of those conditions.
Group V: Adaptive spacing, then low-item non-adaptive spacing, then high-item non-adaptive spacingExperimental Treatment3 Interventions
All participants will receive all three naming treatment conditions in a randomized order - this is one possible ordering of those conditions.
Group VI: Adaptive spacing, then high-item non-adaptive spacing, then low-item non-adaptive spacingExperimental Treatment3 Interventions
All participants will receive all three naming treatment conditions in a randomized order - this is one possible ordering of those conditions.
Find a Location
Who is running the clinical trial?
University of PittsburghLead Sponsor
1,723 Previous Clinical Trials
16,343,124 Total Patients Enrolled
3 Trials studying Aphasia
66 Patients Enrolled for Aphasia
University of Massachusetts, AmherstOTHER
78 Previous Clinical Trials
467,740 Total Patients Enrolled
2 Trials studying Aphasia
54 Patients Enrolled for Aphasia
National Institute on Deafness and Other Communication Disorders (NIDCD)NIH
330 Previous Clinical Trials
178,439 Total Patients Enrolled
37 Trials studying Aphasia
2,757 Patients Enrolled for Aphasia
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- You have trouble understanding and speaking language, based on a specific test score.I have had difficulty speaking for over 6 months due to a stroke.I have a severe mood or behavioral disorder that needs special mental health care.You have trouble with at least two out of eight parts of the Comprehensive Aphasia Test.I have a history of a progressive neurological condition.You are not able to control your drug or alcohol use.
Research Study Groups:
This trial has the following groups:- Group 1: High-item non-adaptive spacing, then adaptive spacing, then low-item non-adaptive spacing
- Group 2: Adaptive spacing, then high-item non-adaptive spacing, then low-item non-adaptive spacing
- Group 3: Adaptive spacing, then low-item non-adaptive spacing, then high-item non-adaptive spacing
- Group 4: High-item non-adaptive spacing, then low-item non-adaptive spacing, then adaptive spacing
- Group 5: Low-item non-adaptive spacing, then high-item non-adaptive spacing, then adaptive spacing
- Group 6: Low-item non-adaptive spacing, then adaptive spacing, then high-item non-adaptive spacing
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Is enrollment for this research still open?
"As per the information on clinicaltrials.gov, this medical trial has ceased recruitment of patients. It was first published in February 1st 2023 and last updated December 7th 2022; however, there are 1101 other studies actively recruiting at present."
Answered by AI
What ultimate goals are researchers seeking to achieve through this research endeavor?
"This trial intends to track the transformation in correct responses of treated and untreated pictured objects over an initial assessment window (pre-treatment) followed by a 3 month post-treatment period. Secondary objectives include measuring changes in mean scores on the Aphasia Communication Outcome Measure Short-Form, Comprehensive Aphasia Test (CAT), and S/P Weights from Philadelphia Naming Tests. The latter two tests are used respectively to gauge semantic and phonological ability which contribute towards effective communication functioning."
Answered by AI
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