PET/MRI Imaging for ACL Injury

Overseen By Michael V Knopp, MD, PhD

Age: 18 - 65

Sex: Any

Trial Phase: Academic

Sponsor: University of Cincinnati

Disqualifiers: Pregnancy, Renal insufficiency, Bioimplants, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 1

66 Participants Needed

Trial Summary

What is the purpose of this trial?

The objective of this study is to answer the following questions: 1. Does the appearance of the reconstructed anterior cruciate ligament (ACL) vary in appearance on PET/MRI depending on graft type and time after surgery? 2. What is the appearance of the native ACL on Positron Emission Tomography/Magnetic Resonance Imaging (PET/MRI)?

Research Team

Michael V Knopp, MD, PhD

Principal Investigator

Ohio State University

Eligibility Criteria

This trial is for men and women aged 18-60 who are scheduled for a standard MRI at OSU. It's not suitable for those with certain bioimplants, metal in their body, pregnant or lactating individuals, prisoners, people unable to consent, those with severe kidney issues or metallic tattoos, and anyone anxious about MRIs.

Inclusion Criteria

Patients scheduled for a standard of care MRI at OSU

Exclusion Criteria

I have metal clips or staples from past surgery.

I might have an ACL injury.

My kidney function is significantly reduced.

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Imaging Assessment

Participants undergo a low dose FDG PET scan and a standard of care MRI to assess the vascularity and metabolic activity of the ACL graft.

1 day

1 visit (in-person)

Follow-up

Participants are monitored for safety and effectiveness after imaging assessment.

2-5 years

Treatment Details

Interventions

• MRI scan
• PET scan

Trial Overview The study aims to understand how the reconstructed ACL looks on PET/MRI scans depending on graft type and time post-surgery. It also examines the appearance of native ACLs using these imaging techniques.

Participant Groups

Group I: Patient population without ACL injury or reconstruction Experimental Treatment 2 Interventions

Group II: Patient population with ACL injury or reconstruction Experimental Treatment 2 Interventions

Who Is Running the Clinical Trial?

University of Cincinnati

Lead Sponsor

Trials

442

Recruited

639,000+

Ohio State University

Lead Sponsor

Trials

891

Recruited

2,659,000+