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Transcranial Stimulation for Alcoholism

N/A
Recruiting
Led By John E Desmond, PhD
Research Sponsored by Johns Hopkins University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 4 minutes and 40 seconds
Awards & highlights

Study Summary

This trial seeks to understand how the cerebellum is involved in the reward system in people with AUD, and if a therapy using cerebellar transcranial stimulation can be used to modulate alcohol cue reactivity & cravings.

Who is the study for?
This trial is for individuals with Alcohol Use Disorder who have completed at least 8 years of education. It's not suitable for left-handed people, non-native English speakers, those with serious medical conditions or liver issues, metal implants incompatible with MRI scans, pregnant women, low IQ (<90), current drug use (except nicotine/caffeine), or central nervous system disorders.Check my eligibility
What is being tested?
The study investigates the cerebellum's role in the brain reward system affected by AUD. It examines how cerebellar input to the VTA is altered in AUD and explores if cerebellar transcranial direct current stimulation can reduce alcohol craving and affect brain connectivity.See study design
What are the potential side effects?
While specific side effects are not detailed here, transcranial direct current stimulation may cause mild discomfort like itching or tingling at the electrode site on the scalp during application.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~4 minutes and 40 seconds
This trial's timeline: 3 weeks for screening, Varies for treatment, and 4 minutes and 40 seconds for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Brain activation related to reward prediction during the monetary incentive task
Brain activation to alcohol cues
Brain activation to reward prediction error during the monetary incentive task
+7 more
Secondary outcome measures
Baseline cerebral blood flow (CBF) measured from a CBF MRI scan
Behavioral accuracy during the monetary incentive task

Trial Design

3Treatment groups
Experimental Treatment
Placebo Group
Group I: Cathodal cerebellar transcranial direct current stimulation (ctDCS)Experimental Treatment1 Intervention
For ctDCS, the cathodal (-) electrode will be positioned over the right cerebellum 1 cm below and 3 cm lateral to the inion, and the anodal (+) electrode will be placed on the contralateral supraorbital area (FP2 EEG location).
Group II: Anodal cerebellar transcranial direct current stimulation (atDCS)Experimental Treatment1 Intervention
For atDCS, anode/cathode locations are reversed from those of ctDCS..
Group III: Sham cerebellar transcranial direct current stimulation (stDCS)Placebo Group1 Intervention
For stDCS, the electrodes will be configured randomly as atDCS 50% of the time, and as ctDCS 50% of the time.

Find a Location

Who is running the clinical trial?

Johns Hopkins UniversityLead Sponsor
2,266 Previous Clinical Trials
14,837,375 Total Patients Enrolled
14 Trials studying Alcoholism
1,905 Patients Enrolled for Alcoholism
National Institute on Alcohol Abuse and Alcoholism (NIAAA)NIH
802 Previous Clinical Trials
1,365,323 Total Patients Enrolled
424 Trials studying Alcoholism
985,746 Patients Enrolled for Alcoholism
John E Desmond, PhDPrincipal InvestigatorJohns Hopkins University

Media Library

Cathodal cerebellar transcranial direct current stimulation (ctDCS) Clinical Trial Eligibility Overview. Trial Name: NCT05732207 — N/A
Alcoholism Research Study Groups: Cathodal cerebellar transcranial direct current stimulation (ctDCS), Anodal cerebellar transcranial direct current stimulation (atDCS), Sham cerebellar transcranial direct current stimulation (stDCS)
Alcoholism Clinical Trial 2023: Cathodal cerebellar transcranial direct current stimulation (ctDCS) Highlights & Side Effects. Trial Name: NCT05732207 — N/A
Cathodal cerebellar transcranial direct current stimulation (ctDCS) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05732207 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any remaining opportunities to participate in the investigation?

"Affirmative. Clinicaltrials.gov's records indicate that this clinical trial is actively recruiting patients since it was first posted on July 17th 2023 and last updated a few days later, on the 27th of July. For now, 122 participants must be found for the medical experiment to take place in one location only."

Answered by AI

Am I eligible to take part in this investigation?

"This trial is seeking 122 individuals with an alcohol abuse disorder aged between 25 and 55. Furthermore, applicants must possess at least 8 years of formal schooling to be eligible for the study."

Answered by AI

Is the eligibility criteria of this experiment open to those who are over seventy years old?

"This trial is limited to those aged between 25 and 55 years old, as per the criteria for inclusion."

Answered by AI

How many individuals are currently being monitored in this investigation?

"Affirmative, the clinicaltrials.gov portal indicates that this trial is actively enrolling patients. The investigation was initially posted on July 17th 2023 and its most recent update was done on 27th of July 2023. Presently, 122 people need to be recruited at a single medical centre."

Answered by AI

Who else is applying?

What site did they apply to?
Johns Hopkins University School of Medicine
What portion of applicants met pre-screening criteria?
Met criteria
Recent research and studies
clinicaltrials.govStudy
Cerebellar Involvement in Alcohol Use Disorder (AUD)
2023. "Cerebellar Involvement in Alcohol Use Disorder (AUD)". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05732207.
~81 spots leftby Apr 2027
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