Hydration Protocol for Aging

(DRIP Trial)

Overseen By Hui Ying Luk, Ph.D.

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: Texas Tech University

Must not be taking: Corticosteroids, NSAIDs, Hormonal therapies, others

Disqualifiers: Pregnancy, Diabetes, Kidney disease, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 4

15 Participants Needed

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to examine how hydration affects inflammation and overall body performance in adults aged 45-65. Participants will follow a Hydration-Dehydration-Rehydration Protocol (HDR) routine to assess its impact on inflammation markers and physical strength. Individuals who are generally healthy, have a BMI under 30, and weigh at least 110 pounds may be suitable candidates. As an unphased trial, this study provides a unique opportunity to contribute to foundational research on hydration's impact on health.

Will I have to stop taking my current medications?

Yes, you will need to stop taking medications that affect fluid retention, such as corticosteroids, NSAIDs, hormonal therapies, antihypertensives, psychiatric medications, vasodilators, diuretics, and RAAS inhibitors.

What prior data suggests that this hydration-dehydration-rehydration protocol is safe for adults aged 45-65?

Research shows that the Hydration-Dehydration-Rehydration (HDR) Protocol involves managing water intake over 12 days to observe its effects on the body. This includes periods of increased water consumption, reduced intake, and rehydration.

Monitoring health closely during this process ensures safety. Researchers will track kidney function and check blood salt levels to confirm the body handles changes in water intake effectively.

Although the mild dehydration in this study is less risky than severe dehydration, it still requires careful attention to prevent any issues. Other studies have safely used this method to explore the effects of dehydration and rehydration. ^{1 2 3 4 5}

Why are researchers excited about this trial?

Researchers are excited about the Hydration-Dehydration-Rehydration (HDR) Protocol because it takes a unique approach to improving hydration in aging individuals. Unlike traditional hydration methods that focus solely on fluid intake, the HDR Protocol involves a cycle of hydration, dehydration, and rehydration over a 12-day period, potentially offering insights into optimal fluid management for older adults. This method aims to enhance the body's ability to manage and utilize fluids effectively, which could lead to better hydration strategies and improved overall health for the aging population.

What evidence suggests that this hydration protocol is effective for improving physiological performance in adults aged 45-65?

Research shows that staying hydrated is crucial for the body, especially with age. Studies have found that adequate water intake supports brain function. Insufficient hydration can lead to increased inflammation and sleep disturbances. Drinking enough fluids can alleviate these issues and improve overall well-being. In this trial, participants will follow the Hydration-Dehydration-Rehydration Protocol to examine how hydration changes affect inflammation, cellular energy, and physical performance. Staying hydrated is a simple yet vital way to maintain health as we age. ^{1 2 6 7 8}

Are You a Good Fit for This Trial?

This trial is for apparently healthy adults aged 45-65 with a BMI less than 30 kg/m2 and body weight of at least 110 lbs. It's designed to explore how hydration affects inflammation and bodily functions.

Inclusion Criteria

I am generally in good health.

My BMI is under 30.

My body weight is at least 110 lbs.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1 day

1 visit (in-person)

Hydration

Participants undergo a 4-day hydration protocol to assess baseline physiological parameters

4 days

1 visit (in-person) for pre-hydration testing

Dehydration

Participants undergo a 4-day mild dehydration protocol to evaluate changes in physiological performance

4 days

1 visit (in-person) for post-dehydration testing

Rehydration

Participants undergo a 4-day rehydration protocol to assess recovery of physiological parameters

4 days

1 visit (in-person) for post-rehydration testing

Follow-up

Participants are monitored for changes in hydration status and physiological performance

6 days

Continuous monitoring using wearable devices

What Are the Treatments Tested in This Trial?

Interventions

• Hydration-Dehydration-Rehydration Protocol (HDR)

Trial Overview Participants will undergo a Hydration-Dehydration-Rehydration (HDR) protocol over 12 days, assessing the impact on inflammatory markers, mitochondrial health, blood glucose levels, sleep quality, and physical strength.

How Is the Trial Designed?

Group I: Hydration-Dehydration-Rehydration (HDR) Protocol Arm Experimental Treatment 1 Intervention

Participants in this arm complete the HDR Protocol over 12 days and attend five lab visits.

Who Is Running the Clinical Trial?

Texas Tech University

Lead Sponsor

Trials

89

Recruited

10,300+

Citations

1. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC10255140/

Hydration Status in Older Adults: Current Knowledge and ... Several studies have demonstrated that cognitive performance is associated with hydration status in older people [78,79].

2. clinicaltrials.gov clinicaltrials.gov/study/NCT07084675?firstPost=2021-01-13_&viewType=Table&rank=7

Dehydration, Rehydration, and Impact on Physiology The HDR Protocol is a 12-day, sequential fluid manipulation intervention designed to assess the physiological effects of controlled changes in hydration status.

3. sciencedirect.com sciencedirect.com/science/article/pii/S1279770723023072

Preventing and treating dehydration in the elderly during ... The most important strategy is simply a matter of ensuring that elderly people consume a sufficient amount of fluids (at least 1.7 liters every 24 hours).

4. ncbi.nlm.nih.gov ncbi.nlm.nih.gov/books/NBK555956/

Adult Dehydration - StatPearls - NCBI Bookshelf - NIH Mild-to-moderate dehydration typically has an excellent prognosis with prompt oral or IV rehydration. However, severe dehydration carries a ...

5. mdpi.com mdpi.com/2072-6643/17/14/2256

Hydration Strategies in Older Adults An effective hydration strategy includes drinking fluids before exercise, consistent hydration during physical activity (approximately every 15 to 20 min), and ...

6. emedicine.medscape.com emedicine.medscape.com/article/906999-treatment

Dehydration Treatment & Management: Medical Care, Diet, ... Severe dehydration warrants hospital admission for rehydration with isotonic saline, as do hypernatremic or hyponatremic states.

7. medicalguidelines.msf.org medicalguidelines.msf.org/en/viewport/CHOL/english/5-4-some-dehydration-32409711.html

5.4 Some dehydration Patients with some dehydration are not as critically ill as those with severe dehydration, but are at high risk of becoming so.

8. science.gov science.gov/topicpages/o/oral+rehydration+therapy

oral rehydration therapy: Topics by ... Patients were allowed to drink water until two hours before the surgery. Gastric fluid was aspirated with a gastric tube after anesthesia induction, after which ...