Powerbreathe for Heart Failure
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial investigates how the breathing exercise device, Powerbreathe, combined with cardiac rehab, can improve heart function in people with heart failure. Researchers will compare two groups: one using the device at a low setting and the other at a higher setting. Ideal candidates for this trial are those living with heart failure, who have not been hospitalized recently, and can exercise without major issues. As an unphased trial, this study offers a unique opportunity to contribute to innovative research that could enhance treatment options for heart failure.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop your current medications. However, it mentions that participants should be on guideline-directed medical therapy for heart failure for more than 6 weeks, so you may need to continue your current heart failure medications.
What prior data suggests that this device is safe for heart failure patients?
Studies have shown that inspiratory muscle training (IMT) is generally safe for people with heart failure. This training strengthens the muscles used for breathing. Research indicates that it can improve the coordination of heart and lung function without causing major problems.
For example, one study found that IMT can safely enhance heart failure patients' ability to perform daily activities. Another review of studies showed that IMT did not cause serious side effects. These findings suggest that Powerbreathe, a device used for IMT, is well-tolerated. While individual experiences can vary, current evidence supports the safety of this treatment for improving heart and lung function in those with heart failure.12345Why are researchers excited about this trial?
Most treatments for heart failure, like medications or devices, aim to manage symptoms or improve heart function. But Powerbreathe is different because it focuses on strengthening the respiratory muscles using a technique called inspiratory muscle training (IMT). Unlike traditional methods, this approach could enhance breathing efficiency and potentially boost overall heart health. Researchers are excited because if successful, it offers a non-invasive, drug-free option to support heart failure patients in a unique way.
What evidence suggests that Powerbreathe is effective for heart failure?
This trial will compare two approaches to inspiratory muscle training (IMT) for heart failure. Research has shown that IMT strengthens breathing muscles and improves quality of life for people with heart failure. It also reduces certain heart stress markers. In this trial, one group will perform IMT at 40% maximal inspiratory pressure (MIP), while another group will perform a sham IMT at 5% MIP. IMT is especially recommended for those with long-term heart failure and other heart conditions. Overall, IMT improves breathing and heart health in these patients.678910
Who Is on the Research Team?
Joshua Smith, Ph.D.
Principal Investigator
Mayo Clinic
Are You a Good Fit for This Trial?
This trial is for heart failure patients with a BMI ≤45 kg/m2, who can exercise and have been on heart medications for over 6 weeks. They should be non-smokers or have quit long ago, without recent hospitalizations, and not severely limited by other health issues.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo inspiratory muscle training (IMT) combined with cardiac rehabilitation (CR) for 12 weeks
Follow-up
Participants are monitored for changes in cardiovascular function and exercise responses
What Are the Treatments Tested in This Trial?
Interventions
- Powerbreathe
Find a Clinic Near You
Who Is Running the Clinical Trial?
Mayo Clinic
Lead Sponsor
National Heart, Lung, and Blood Institute (NHLBI)
Collaborator