Evaluation of Stool Based Markers for the Early Detection of Colorectal Cancers and Adenomas
What You Need to Know Before You Apply
What is the purpose of this trial?
Colon cancer is the second most common cancer in men and women. It is a disease that can be prevented if it is found early. Colonoscopy is still the best screening tool for colon cancer and the polyps that turn into colon cancer. However, due to a variety of factors, including affordability, time, and age, not all patients are able to be screened. Researchers are working on other options for early detection that are as accurate as colonoscopy.The purpose of this study if to determine if stool or blood can be used to detect colon cancers as early or earlier than colonoscopy. The researchers plan to use these samples to learn about specific proteins (also known as biomarkers) that may indicate colon polyps, colon cancer or an increased risk of developing colon cancer. In order to learn more about preventing and detecting colon and rectal cancer, we are collecting samples from subjects with cancer, adenomas, and colonoscopies who may be at risk for polyps.
Who Is on the Research Team?
Dean E Brenner, M.D.
Principal Investigator
University of Michigan
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Biospecimen Collection
Collection of stool, blood, serum, plasma, and tissue samples from subjects
Biomarker Analysis
Analysis of individual biomarkers and construction of a panel of markers for future screening trials
Follow-up
Participants are monitored for safety and effectiveness after biospecimen collection
What Are the Treatments Tested in This Trial?
Interventions
- Colonoscopy
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Michigan Rogel Cancer Center
Lead Sponsor
Early Detection Research Network
Collaborator
Clinical Genomics Pathology
Industry Sponsor
National Cancer Institute (NCI)
Collaborator
Great Lakes New England Clinical Validation Center
Collaborator
VolitionRx
Collaborator
Department of Health and Human Services
Collaborator