Home-Based Exercise for Endometrial Cancer Survivors

Overseen By Clinical Trials Referral Office

Age: 18+

Sex: Female

Trial Phase: Academic

Sponsor: Mayo Clinic

Disqualifiers: Paraplegia, Hemiplegia, No English, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: Unknown

Duration: 10 weeks

80 Participants Needed

Trial Summary

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications.

What data supports the effectiveness of the treatment Remote Home-Based Exercise Program for endometrial cancer survivors?

Research shows that home-based exercise programs can be feasible and acceptable for endometrial cancer survivors, and similar programs have been effective in improving fitness in breast cancer survivors, suggesting potential benefits for endometrial cancer survivors as well. ^{1 2 3 4 5}

Is home-based exercise safe for endometrial cancer survivors?

Research suggests that home-based exercise programs, including strength training, are generally safe for endometrial cancer survivors. These programs can be done without supervision, but it's important for individuals to consider their own health conditions and consult with healthcare providers before starting. ^{1 2 3 4 6}

How is the Home-Based Exercise Program treatment different from other treatments for endometrial cancer survivors?

The Home-Based Exercise Program is unique because it allows endometrial cancer survivors to engage in muscle-strengthening activities from the comfort of their own homes, making it more accessible and convenient compared to traditional supervised rehabilitation programs. This approach can help improve physical health and is tailored to be safe for those with additional health conditions. ^{1 2 3 4 5}

What is the purpose of this trial?

This clinical trial studies how well a remotely delivered home-based exercise program for strength training works to positively impact endometrial cancer (EC) survivorship for patients with decreased cancer survivorship access. Cancer survivors in rural areas face barriers to supportive care, including geographic and environmental barriers to exercise and technology. Rural areas in the Midwest are underserved in terms of cancer care thus, it is essential to develop and test interventions that are scalable and can reach many individuals including those living in rural areas. Remotely-delivered exercise intervention approach allows for cancer survivors who may live far away from their primary treatment center to engage in supportive therapy via exercise interventions delivered in a sustainable context. In addition, historically black, hispanic and native endometrial cancer survivors have shorter survival and less access to survivorship care, so alternative models for healthcare delivery are needed in this underserved group. Information gained from this research may help determine whether utilizing a remotely delivered exercise program can positively impact EC survivorship for patients with decreased cancer survivorship access.

Research Team

Amanika Kumar, M.D.

Principal Investigator

Mayo Clinic in Rochester

Eligibility Criteria

This trial is for endometrial cancer survivors living in rural areas, especially those who face challenges accessing supportive care. It aims to include individuals from underserved communities such as historically black, Hispanic, and Native populations. Participants should be able to engage in a home-based exercise program delivered remotely.

Inclusion Criteria

I am 50 years old or older.

Primary residence in rural-urban commuting area (RUCA) codes 4.0 through 10.0 or of American Indian, Alaskan Native, Black or Hispanic background

Internet access

Exclusion Criteria

I am paralyzed on one side of my body or from the waist down.

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants engage in a home-based exercise program with resistance band and body weight exercises targeting major muscle groups, along with weekly exercise coaching sessions over 10 weeks.

10 weeks

Weekly virtual coaching sessions

Follow-up

Participants are monitored for changes in physical function and satisfaction with the program after completion of the exercise intervention.

6 months

Treatment Details

Interventions

• Remote Home-Based Exercise Program

Trial Overview The study tests a remote exercise program designed for strength training at home. It examines if this approach can improve the quality of life and physical performance for endometrial cancer survivors with limited access to traditional survivorship care.

Participant Groups

Group I: Supportive Care (home-based exercise program) Experimental Treatment 7 Interventions

Participants participate in a home-based exercise program with an exercise prescription that will include resistance band and body weight exercises targeting the 5 major large muscle groups along with 3 booklets about exercise and exercise training and attend weekly exercise coaching sessions to report on exercise adherence and to progress exercise over 10 weeks on study.

Who Is Running the Clinical Trial?

Mayo Clinic

Lead Sponsor

Trials

3,427

Recruited

3,221,000+

Findings from Research

A home-based muscle strengthening program for endometrial cancer survivors was found to be feasible, with 75% of participants adhering to the twice-weekly exercise schedule over 10 weeks and high satisfaction reported.

The program was safe, with no injuries or adverse events reported, indicating that such interventions can be effectively implemented for cancer survivors to promote physical activity.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Feasibility and acceptability of home-based strength training in endometrial cancer survivors. Gorzelitz, J., Costanzo, E., Gangnon, R., et al.[2023]

A systematic review of 58 publications identified 34 exercise programs for cancer survivors conducted in home or community settings, highlighting the diversity of interventions available.

The review revealed significant gaps in reporting on the implementation processes and contextual factors affecting these programs, indicating a need for more detailed studies to enhance future community-based exercise interventions for cancer survivors.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Community-Based Exercise Programs for Cancer Survivors: A Scoping Review of Program Characteristics Using the Consolidated Framework for Implementation Research. Neil-Sztramko, SE., Smith-Turchyn, J., Fong, A., et al.[2022]

Only 14.2% of endometrial cancer patients were found to be suitable for unsupervised exercise programs based on their health status at diagnosis, which increased to 20.5% when excluding common comorbidities like hypertension and diabetes.

The study indicates that a significant majority (approximately 80%) of endometrial cancer patients may require referral to medically-supervised exercise programs due to health issues that could hinder their ability to safely engage in unsupervised exercise.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

The prescription or proscription of exercise in endometrial cancer care. Zhang, X., Haggerty, AF., Brown, JC., et al.[2018]

An in-home rehabilitation program utilizing mobile technology significantly reduced urinary incontinence (UI) severity in 87.5% of endometrial cancer survivors, demonstrating a moderate treatment effect.

The study highlights the potential of mobile technology to improve access to pelvic floor physiotherapy, especially for survivors living in rural and remote areas, addressing a critical gap in care.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

An in-home rehabilitation program for the treatment of urinary incontinence symptoms in endometrial cancer survivors: a single-case experimental design study. Bernard, S., McLean, L., Boucher, S., et al.[2022]

A home-based exercise program for breast cancer survivors significantly improved upper body strength and shoulder range of motion after 16 weeks, involving 89 women aged around 55 years.

However, the intervention did not lead to significant changes in overall physical fitness, sedentary behavior, or disability measures, suggesting that additional strategies may be needed to enhance broader health outcomes.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Effectiveness of a Home-Based Exercise Intervention in the Fitness Profile of Hispanic Survivors of Breast Cancer. Ortiz, A., Hughes, DC., Mama, SK., et al.[2022]

A 10-week home-based strength training program for 40 post-treatment endometrial cancer survivors resulted in significant improvements in physical function, particularly in chair sit-to-stand, arm curls, and mobility tests.

Despite these functional gains, there were no significant changes in body composition or blood biomarkers, indicating that strength training can enhance physical capabilities without necessarily affecting weight or metabolic markers.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Improvements in strength and agility measures of functional fitness following a telehealth-delivered home-based exercise intervention in endometrial cancer survivors. Gorzelitz, JS., Stoller, S., Costanzo, E., et al.[2023]

References

1. United States pubmed.ncbi.nlm.nih.gov

Feasibility and acceptability of home-based strength training in endometrial cancer survivors. [2023]

2. United States pubmed.ncbi.nlm.nih.gov

Community-Based Exercise Programs for Cancer Survivors: A Scoping Review of Program Characteristics Using the Consolidated Framework for Implementation Research. [2022]

3. United States pubmed.ncbi.nlm.nih.gov

The prescription or proscription of exercise in endometrial cancer care. [2018]

4. England pubmed.ncbi.nlm.nih.gov

An in-home rehabilitation program for the treatment of urinary incontinence symptoms in endometrial cancer survivors: a single-case experimental design study. [2022]

5. United States pubmed.ncbi.nlm.nih.gov

Effectiveness of a Home-Based Exercise Intervention in the Fitness Profile of Hispanic Survivors of Breast Cancer. [2022]

6. Germany pubmed.ncbi.nlm.nih.gov

Improvements in strength and agility measures of functional fitness following a telehealth-delivered home-based exercise intervention in endometrial cancer survivors. [2023]