Anesthesia for Stroke
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to determine which type of anesthesia, inhaled or intravenous, leads to better outcomes for people undergoing surgery after a stroke. Specifically, it compares inhaling sevoflurane (an inhaled anesthetic) to receiving propofol through an IV (an intravenous anesthetic). The goal is to identify which method benefits patients more during surgery for a stroke. The trial seeks participants who have experienced an ischemic stroke and are scheduled for endovascular treatment. As an unphased trial, it offers participants the chance to contribute to important research that could enhance surgical outcomes for stroke patients.
What prior data suggests that these anesthesia techniques are safe for stroke patients?
Research has shown that sevoflurane and propofol are both commonly used anesthesia drugs with specific safety records. Sevoflurane may protect the brain when used before and after a stroke, potentially reducing nerve damage and swelling. However, it can sometimes lower blood pressure and reduce blood flow to the brain.
Propofol has improved recovery from strokes compared to other anesthetics like isoflurane, causing less harm to brain tissue. Although limited information exists on its safety specifically for stroke patients, it is generally well-tolerated and widely used in medical settings.
Overall, both sevoflurane and propofol have been used safely in medical procedures. Studies suggest that while each has some side effects, they are usually manageable, making them suitable for many patients with careful medical supervision.12345Why are researchers excited about this trial?
Unlike the standard stroke care, which often focuses on clot-busting drugs or mechanical thrombectomy, the use of anesthesia like sevoflurane and propofol is unique in managing acute ischemic stroke. Sevoflurane, administered through inhalation, acts quickly and might provide neuroprotective effects by reducing brain metabolism and possibly limiting damage. Propofol, given intravenously, is known for its potential to reduce brain activity and protect the brain during stroke. Researchers are excited because these anesthesia methods could offer new ways to protect the brain during a stroke, potentially improving outcomes when combined with existing treatments.
What evidence suggests that this trial's anesthesia techniques could be effective for stroke surgery?
This trial will compare sevoflurane and propofol as anesthesia for patients treated for acute ischemic stroke. Studies have shown that sevoflurane can improve recovery after a stroke by reducing damage and aiding healing. Research indicates that propofol, administered intravenously, may lead to better recovery compared to anesthetics like isoflurane. Propofol might reduce the size of the stroke-affected area and help patients regain independence. Both treatments show promise in enhancing stroke recovery.15678
Who Is on the Research Team?
Arun George, MD
Principal Investigator
University of Kansas Medical Center
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive either inhalational sevoflurane or intravenous propofol infusion as anesthesia during mechanical thrombectomy for acute ischemic stroke
Follow-up
Participants are monitored for functional independence and disability using the modified Rankin Scale (mRS) and other measures
What Are the Treatments Tested in This Trial?
Interventions
- Propofol
- Sevoflurane
How Is the Trial Designed?
2
Treatment groups
Active Control
When treated for acute ischemic stroke, patient will receive inhalation sevoflurane as anesthesia
When treated for acute ischemic stroke, patient will receive intravenous propofol infusion as anesthesia
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Kansas Medical Center
Lead Sponsor
Citations
Propofol anesthesia improves stroke outcomes over isoflurane ...
The primary outcome, lesion size at follow-up after four days, was significantly reduced in the propofol group compared to the isoflurane group, ...
Effects of Volatile Anesthetics on Postoperative Ischemic ...
BackgroundPreclinical studies suggest that volatile anesthetics decrease infarct volume and improve the outcome of ischemic stroke.
Isoflurane vs. Propofol Sedation in Patients with Severe ...
This comparative study compared the efficacy of achieving target sedation depth using inhaled (isoflurane) versus intravenous (propofol) sedation.
Propofol anesthesia improves stroke outcomes over ...
Emerging evidence suggests propofol may have superior effects on disability and/or mortality rates, but a mode-of-action underlying these class- ...
Effects of general anesthesia on short-term outcomes ...
Collectively, these studies enrolled 1,674 patients with acute ischemic stroke (AIS) caused by large vessel occlusion (LVO) in either the anterior (internal ...
Safety and Hemodynamic Profile of Propofol and ...
There is limited data on the safety, hemodynamic profile, and outcome of patients undergoing intra-arterial therapy (IAT) for acute ischemic stroke (AIS) under ...
Safety and Hemodynamic Profile of Propofol and ...
There was no difference in good clinical outcome or in-hospital mortality in patients undergoing IAT for AIS using DEX versus PROP sedation.
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journals.lww.com
journals.lww.com/md-journal/fulltext/2019/05240/the_safety_and_efficacy_of_dexmedetomidine_versus.24.aspxThe safety and efficacy of dexmedetomidine versus ...
Both dexmedetomidine and propofol have been used in patients for acute stroke. It is uncertain which one is better for patients with acute stroke.
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