DispersinB Cleanser for Acne

Overseen By Clinical Research Coordinator

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: Kane Biotech Inc

Must not be taking: Vitamin A, Testosterone

Disqualifiers: Pregnancy, Excessive facial hair, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 5

Duration: 12 weeks

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to evaluate the effectiveness and skin tolerance of DispersinB Acne Cleanser when used with Benzoyl Peroxide, a common acne treatment. Researchers will compare the effects on each side of the face to determine if adding DispersinB improves acne clearance. Individuals with mild to moderate acne and an even number of acne spots on both sides of their face may be suitable candidates for this study. As an unphased trial, this study provides a unique opportunity to contribute to the understanding of new acne treatment combinations.

Do I need to stop my current medications to join the trial?

Yes, you may need to stop certain medications before joining the trial. There are specific 'washout' periods (time without taking certain medications) for various treatments, such as 2 weeks for topical treatments and up to 12 weeks for some systemic treatments like oral retinoids.

What prior data suggests that the DispersinB Acne Cleanser is safe for treating acne?

Research has shown that DispersinB Acne Cleanser is under study to determine its effectiveness in improving acne treatment. One study found that DispersinB can enhance the efficacy of benzoyl peroxide, a common acne treatment, by making bacteria more susceptible. This combination might allow for lower doses of benzoyl peroxide, potentially reducing the risk of side effects.

Specific safety information about DispersinB Acne Cleanser in humans remains limited, as it is still under testing. However, since it is tested alongside benzoyl peroxide, which is widely used and generally safe for most people, there is some confidence in its safety. Benzoyl peroxide can sometimes cause mild skin irritation, such as redness or dryness, but these effects are usually manageable.

The trial is in an early stage, focusing on testing the concept and assessing tolerance. Researchers are still gathering safety information, so participants must report any side effects they experience. ^{1 2 3 4 5}

Why are researchers excited about this trial?

DispersinB Acne Cleanser is unique because it targets acne by disrupting biofilms, which are protective layers that bacteria form on the skin. Most standard acne treatments, like topical antibiotics and benzoyl peroxide, focus on killing bacteria or reducing inflammation. However, DispersinB takes a different approach by breaking down these biofilms, potentially making it easier to clear acne-causing bacteria. This distinct mechanism could lead to more effective treatment outcomes and is why researchers are excited about its potential.

What evidence suggests that DispersinB Acne Cleanser might be an effective treatment for acne?

Research has shown that DispersinB Acne Cleanser can greatly reduce the bacteria that cause acne. In this trial, participants will apply DispersinB to one side of the face and a 4% benzoyl peroxide facial wash to the entire face for a split-face comparison. Previous studies have demonstrated that combining DispersinB with benzoyl peroxide reduces acne bacteria more effectively than using DispersinB alone. This combination significantly decreases the bacteria responsible for acne. The treatment works well with benzoyl peroxide, a common acne treatment, suggesting it could help clear skin more effectively. These findings support the idea that DispersinB Acne Cleanser may be effective in treating acne. ^{1 6 7 8 9}

Who Is on the Research Team?

Prinicipal Investigator

Principal Investigator

University of Miami

Are You a Good Fit for This Trial?

This trial is for adults with mild to moderate acne vulgaris. Participants will treat one side of their face with DispersinB Acne Cleanser and the other side with a standard treatment, allowing researchers to compare results directly on each person.

Inclusion Criteria

2. Subject with clinical diagnosis of acne vulgaris on the face as defined by Investigator's Global Assessment (IGA) score of 2 (Mild) or 3 (Moderate), with the same score on both sides of the face.

3. Subject with a symmetrical number of lesions on the whole face.

4. The subject is a female of childbearing potential is willing to undergo UPTs throughout the study.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

4 weeks

1 visit (in-person)

Treatment

Participants apply DispersinB Acne Cleanser and 4% Benzoyl Peroxide for a split-face comparison over a 12-week period

12 weeks

4 visits (in-person) at weeks 2, 4, 8, and 12

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

• DispersinB Acne Cleanser

Trial Overview The study tests if DispersinB Acne Cleanser can improve acne when used alongside Benzoyl Peroxide compared to using Benzoyl Peroxide alone. It's an intra-individual comparison over 12 weeks, focusing on how many people achieve clear skin and the change in number of acne lesions.

How Is the Trial Designed?

Group I: intra-individual Split-face comparison Experimental Treatment 1 Intervention

Subjects will complete baseline assessments and be randomized (left face versus right face) to apply DispersinB Acne Cleanser over at 12-week treatment period, for an intra-individual, split-face comparison. Subjects will use the DispersinB Acne Cleanser on the assigned facial side for 5 minutes and then will use the provided 4% Benzoyl peroxide facial wash to wash entire face for daily (evening) use.

Who Is Running the Clinical Trial?

Kane Biotech Inc

Lead Sponsor

Trials

1

Recruited

20+

University of Miami

Collaborator

Trials

976

Recruited

423,000+

Citations

1. clinicaltrials.gov clinicaltrials.gov/ct2/show/NCT06729450

Efficacy and Tolerability of DispersinB Acne Cleanser in ... This is a single-center study using intra-individual comparison (right half-face versus left half-face) to evaluate the efficacy and tolerability of DispersinB ...

2. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov/40146741

Synergistic activity of dispersin B and benzoyl peroxide ... Dispersin B or BP alone reduced C. acnes colony-forming units (CFUs) by 1-2 log units. However, sequential treatment with dispersin B followed ...

3. msn.com msn.com/en-us/money/savingandinvesting/kane-biotech-s-new-acne-treatment-study-what-investors-need-to-know/ar-AA1Piu5d

Kane Biotech's New Acne Treatment Study: What Investors ... ' The study aims to evaluate the effectiveness and tolerability of DispersinB Acne Cleanser in treating facial acne. The primary objectives include assessing ...

4. cbs17.com cbs17.com/business/press-releases/globenewswire/9393821/kane-biotech-secures-irb-approval-to-launch-innovative-dispersinb-acne-trial/

Kane Biotech Secures IRB Approval to Launch Innovative ... The title of the study is “Split-face efficacy and tolerability of DispersinB® Acne Cleanser in the treatment of mild to moderate Acne Vulgaris.

5. theglobeandmail.com theglobeandmail.com/investing/markets/markets-news/GetNews/34269800/acne-vulgaris-market-outlook-2034-clinical-trials-market-size-medication-prevalence-companies-by-delveinsight/

Acne Vulgaris Market Outlook 2034 – Clinical Trials, Market Size, ... In April 2025, Dermata reported Phase III results showing XYNGARI achieved significant efficacy, separating from placebo after four weekly treatments, ...

6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC11949332/

Synergistic activity of dispersin B and benzoyl peroxide ... This study evaluated the efficacy of the PNAG-degrading enzyme dispersin B in enhancing the susceptibility of C. acnes biofilms to benzoyl peroxide (BP), a ...

7. journals.plos.org journals.plos.org/plosone/article?id=10.1371/journal.pone.0320662

Synergistic activity of dispersin B and benzoyl peroxide ... The use of dispersin B in combination with BP could therefore be a promising strategy for acne treatment and prevention, as it may reduce the minimum effective ...

8. researchgate.net researchgate.net/publication/259826018_Antibiofilm_and_Antimicrobial_Efficacy_of_DispersinBR-KSL-W_Peptide-Based_Wound_Gel_Against_Chronic_Wound_Infection_Associated_Bacteria

KSL-W Peptide-Based Wound Gel Against Chronic ... As the conventional treatment modalities have proven ineffective, this study provides the in vitro evidence to support the use of a novel ...

9. cir-safety.org cir-safety.org/sites/default/files/116_draft_triclo.pdf

GREEN BOOK 1 Triclosan CIR EXPERT PANEL MEETING ... One study was cited by the European Commission in their analysis of public input on their 2009 opinion on triclosan safety that was not listed ...