Tobacco product administration and assessment for Electronic Nicotine Delivery System Flavors

"Recent findings indicate that E-NDS flavor preference was primarily due to the flavors' pleasurability rather than their perceived health-promoting properties. Flavor intensity was not a factor; however, E-NDS flavor intensity was associated with higher preference, in the strongest case, reflecting an inherent reward system response common to many electronic devices." - Anonymous Online Contributor

"A unique feature of e-cigarettes is the lack of standardized regulatory requirements governing their flavors, with flavors similar to traditional cigarettes common. These flavors are used primarily by novice users to initiate their vaping habit, and include fruit flavors most commonly used to introduce children to e-cigarette use. As a result, children or adolescents can unknowingly initiate the use of these products. It is unclear whether these flavors have the potential to cause cancer, and clinical trials are needed to establish causal relationships." - Anonymous Online Contributor

"Despite popular use of e-cigarette products in the US, there is not much recent evidence to suggest the prevalence of electronic cigarettes is increasing or they are becoming a mainstream tobacco product among U.S. smokers. Results from a recent paper provide some recent data in this regard." - Anonymous Online Contributor

"These data suggest that the development of an electronic cigarette flavor design that improves the tolerability of the flavor may enhance flavors' ability to effectively deliver nicotine." - Anonymous Online Contributor

"E-cigarettes containing sweet flavors, particularly sucrose, may be particularly appealing to youth and will be less effective in reducing smoking rates than flavors that taste like conventional cigarettes." - Anonymous Online Contributor

"E-cigarettes will remain an important source for nicotine (and potentially other constituents) for some time and so are likely to be part of the'smoking'substance of choice' to some degree. E-cigarette manufacturers and regulators need to anticipate consumer confusion between their products and traditional cigarettes, and anticipate nicotine exposure for those using tobacco substitutes." - Anonymous Online Contributor

"Data from a recent study have shown that the addition of new flavors on e-liquor, such as mango or banana, had no effects. There have been no further findings on improving the flavor properties of e-liquid flavors, and flavors that had been introduced to the market prior to the present study remain the best options for consumers for these products." - Anonymous Online Contributor

"In a recent study, findings of this trial show that in individuals with a recent cigarette use history, smoking a flavored-strip tobacco product is a more effective method of reducing cigarette cue reactivity than is a placebo tobacco product. The data can help policy makers and health care providers make informed decisions about the effectiveness of various tobacco-cessation treatments." - Anonymous Online Contributor

"The introduction of e-cigarettes introduces products with novel product characteristics (i.e. flavors and nicotine delivery system) that may be acceptable to young individuals, as well as to clinicians. They might also be used by tobacco users in addition to cigarette smoking as part of a cessation strategy. Given e-liquids are currently used in clinical and scientific research, clinical evaluation of e-cigarettes might occur more effectively and quickly than with traditional cigarettes, and in a manner similar to other therapeutics/medical products." - Anonymous Online Contributor

"E-cigarettes or e-cigarette liquids contain nicotine and may cause an acute rise in plasma nicotine levels. Plasma nicotine levels are higher from cigarette administration or inhalation of liquids. The acute effects of nicotine in e-cigarettes with or without liquids differ from conventional cigarettes. The acute effects from use of all tested products were similar; i.e. these products were not substantially different in their ability to produce plasma nicotine or to produce acute nicotine-related responses following administration of nicotine. The products tested were not suitable for comparative effectiveness research to conventional cigarettes." - Anonymous Online Contributor

"The latest research for E-cigarettes flavor formulations highlights the importance of cigarette-specific research for flavors to inform the development of acceptable flavors and nicotine replacement therapy in general." - Anonymous Online Contributor

"The effects of electronic NDS flavors, particularly concerning nicotine dependence, are most likely moderate effects. It is likely that many consumers will continue to choose electronic NDS flavors. While several electronic NDS flavors could increase the number of cigarette smokers by attracting existing smokers or inducing never-smokers to begin, the potential negative health effects caused by electronic nicotine delivery systems may outweigh any potential benefits." - Anonymous Online Contributor