LipoLife System for Liposuction

Overseen By Amy Kilian

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: Alma Lasers

Must not be taking: Anticoagulants, NSAIDs

Disqualifiers: Pregnancy, Smoking, Malignancy, Autoimmune, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 1

Duration: 1 day

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to understand how fat cells behave when collected using a special liposuction technique called LipoLife (a liposuction system). The goal is to examine the structure and health of the fat removed during this procedure. It is intended for individuals already planning to undergo liposuction on their abdomen or flanks and willing to donate some of the removed fat for research. Non-smokers scheduled for this type of liposuction, with at least 300 milliliters of fat to be removed, might be suitable candidates. As an unphased study, this research offers a unique opportunity to contribute to scientific understanding without the constraints of traditional clinical trial phases.

Do I need to stop taking my current medications for the trial?

The trial requires that you stop taking anticoagulants (blood thinners) or NSAIDs (pain relievers like aspirin) if you've used them for more than 7 days in a row within 15 days before joining the study. Other medications are not specifically mentioned, so it's best to discuss with the study team.

What prior data suggests that the LipoLife system is safe for laser-assisted liposuction?

Research has shown that the LipoLife system, which uses a laser to assist with liposuction, is safe and generally easy for patients to handle. One study found it has fewer complications compared to regular liposuction, suggesting patients might require fewer follow-up treatments. Another study confirmed the system's safety when using specific energy levels during the procedure. The LipoLife system has undergone various tests, including assessments of the safety of the collected fat tissue. These studies support that the treatment is usually well-tolerated by patients. ^{1 2 3 4 5}

Why are researchers excited about this trial?

Researchers are excited about laser-assisted liposuction with the LipoLife system because it offers a less invasive alternative to traditional liposuction methods. Unlike standard treatments that rely solely on mechanical suction, this approach uses laser technology to liquefy fat, making it easier to remove with less trauma to surrounding tissues. This can potentially lead to quicker recovery times and less post-procedure discomfort for patients. Additionally, the precision of the laser may result in smoother body contouring outcomes, which is a significant advantage over conventional techniques.

What evidence suggests that the LipoLife system is effective for laser-assisted liposuction?

Research has shown that the LipoLife system, used in this trial as a laser-assisted liposuction treatment, preserves more fat cells compared to traditional methods. Studies have found that the fat removed with this system is more even and of better quality. This method also offers benefits such as faster recovery, less post-procedure pain, and firmer skin. These findings suggest that the LipoLife system may be more effective and comfortable for individuals seeking fat reduction and skin tightening. ^{4 6 7 8 9}

Who Is on the Research Team?

William Jason Martin, MD

Principal Investigator

Jason Martin, M.D.

Are You a Good Fit for This Trial?

Inclusion Criteria

The study requires at least 300 milliliters of fat to be collected.

Provided written Informed Consent.

You are planning to have a certain type of cosmetic surgery that involves removing fat from your abdomen and flanks, and you are willing to donate some of that fat for the study.

Exclusion Criteria

You have a history of an autoimmune disorder like Systemic Lupus Erythematosus (SLE).

The investigator believes that you cannot safely participate in the study due to some other reason.

Pregnant or intending to become pregnant during the course of study.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants undergo laser-assisted liposuction with the LipoLife system

1 day

1 visit (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment

6 months

What Are the Treatments Tested in This Trial?

Interventions

• LipoLife system

How Is the Trial Designed?

Group I: Laser-assisted liposuction Experimental Treatment 1 Intervention

Laser-Assisted Liposuction with the LipoLife system.

Who Is Running the Clinical Trial?

Alma Lasers

Lead Sponsor

Trials

10

Recruited

220+

Citations

1. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC9704815/

High-Quality Lipoaspirate Following 1470-nm Radial ... Higher cell viability and enhanced sample quality following laser-assisted liposuction versus mechanical liposuction. J Cosmet, Dermatol Sciences and ...

2. almalasers.it almalasers.it/al_21/wp-content/uploads/2021/10/115_Lipolife_White_Paper_Dotor_quote_H_HR.pdf

LipoLife® - Advanced laser-assisted liposuction, lipo- ... In a recent study evaluating the effectiveness of the device, laser-collected samples presented a significantly larger and more homogenous adipose phase ...

3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC12415858/

Impact of Laser Lipolysis With and Without Liposuction on ... Traditional liposuction is effective for volume reduction but may exacerbate skin laxity in patients with poor dermal elasticity, leading to ...

4. link.springer.com link.springer.com/article/10.1007/s00266-025-05056-8

Laser-Assisted Lipolysis: A Promising Alternative to ... LAL shows clinical advantages including faster recovery times, reduced postoperative pain, and improved skin tightening, especially in small to ...

5. sciencedirect.com sciencedirect.com/science/article/pii/S235234092401000X

Multifrequency low-level laser-assisted lipolysis outcomes. ... This dataset aims to study the outcomes of a new Multifrequency Low-level Laser-Assisted Lipolysis technique in patients with obesity.

6. cdn.clinicaltrials.gov cdn.clinicaltrials.gov/large-docs/63/NCT03800563/Prot_SAP_001.pdf

The Safety and Efficacy of Laser Assisted Liposuction and ... The present multi-center, open-label, prospective study aims to assess the safety and efficacy of LipoLife, laser-assisted liposuction of ...

7. accessdata.fda.gov accessdata.fda.gov/cdrh_docs/pdf17/K171242.pdf

July 14, 2017 Alma Lasers Inc. Janice Hogan, J.D. Regulatory ... Alma Lasers' Alma LipoFlow System is a Suction Lipoplasty System and has been evaluated in nonclinical testing, including adipose viability ...

8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC6250476/

Laser-assisted Lipolysis Burn Safety: Proposed Detailed ... This study is proposing a method to apply safe and effective energy parameters in laser lipolysis, with assessment of their efficacy and safety.

9. onlinelibrary.wiley.com onlinelibrary.wiley.com/doi/pdf/10.1111/jocd.14767

assisted liposuction for body contouring and facial fat grafting The present multi- center, open- label, prospective study aimed to assess the safety and 6- month contouring efficacy of LipoLife. 1470 nm ...