Methadone + Dexmedetomidine + Ketamine for Pain Control in Spinal Surgery
What You Need to Know Before You Apply
What is the purpose of this trial?
This study will investigate whether a combination of three anesthetic medications will reduce intraoperative and postoperative pain in patients undergoing complex spine surgery, and whether it will reduce the use of opioid pain medication after surgery.
Are You a Good Fit for This Trial?
This trial is for English-speaking adults aged 18-79 who can consent for themselves and are undergoing complex spine surgery involving three or more levels. It's not specified who cannot participate.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive the methadone-dexmedetomidine-ketamine medication combination intravenously during anesthesia for complex spine surgery
Postoperative Monitoring
Participants are monitored for opioid consumption and pain scores for 72 hours postoperatively
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Methadone-dexmedetomidine-ketamine combination
Trial Overview
The study tests a mix of three anesthetics—Methadone, Dexmedetomidine, and Ketamine—to see if they help control pain better during and after complex spine surgeries, possibly reducing the need for opioid painkillers post-surgery.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Active Control
Group receiving the methadone-dexmedetomidine-ketamine medication combination intravenously during anesthesia for complex spine surgery.
Group that receives routine anesthesia with opioid medications during complex spine surgery.
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Missouri-Columbia
Lead Sponsor
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