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Non-Opioid Analgesic

Opioids vs Non-Opioids for Postoperative Pain After Knee Surgery

Phase 4

Recruiting

Led By Bruce Piatt, MD

Research Sponsored by Sanford Health

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline, 2 weeks, and 6 weeks post-operatively

Awards & highlights

Study Summary

This trial will compare pain management with opioids versus non-opioids after knee surgery.

Who is the study for?

This trial is for adults aged 18-80 undergoing elective knee arthroscopy, like meniscectomy or loose body removal. It's not for those with a history of chronic opioid use, significant medical issues in the past year, pregnant/nursing women, or anyone unable to consent. People on certain blood thinners or with active ulcers are also excluded.Check my eligibility

What is being tested?

The study compares pain management using opioids (Norco) versus non-opioids (Ibuprofen and Acetaminophen) after knee surgery. It aims to see if non-narcotics can match narcotics' pain relief and how patient characteristics influence post-surgery pain and medication effectiveness.See study design

What are the potential side effects?

Possible side effects include gastrointestinal issues like bleeding or ulcers from Ibuprofen; liver damage from Acetaminophen; and addiction, drowsiness, constipation, nausea from Norco.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline, 2 weeks, and 6 weeks post-operatively

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline, 2 weeks, and 6 weeks post-operatively

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, 2 weeks, and 6 weeks post-operatively for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change from Baseline Medication Use at 2 weeks

Pain

Secondary outcome measures

Change from Baseline Knee Injury and Osteoarthritis Outcome Score (KOOS) at 6 weeks

Change from Baseline Patient Reported Outcome Measurement Information System (PROMIS) at 6 weeks

Trial Design

2Treatment groups

Active Control

Group I: OpioidActive Control1 Intervention

Group II: Non-opioidActive Control2 Interventions

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Sanford HealthLead Sponsor

48 Previous Clinical Trials

61,775 Total Patients Enrolled

Bruce Piatt, MDPrincipal InvestigatorSanford Health

1 Previous Clinical Trials

1 Total Patients Enrolled

Media Library

Acetaminophen 325Mg Tab (Non-Opioid Analgesic) Clinical Trial Eligibility Overview. Trial Name: NCT03858231 — Phase 4

Postoperative Pain Research Study Groups: Opioid, Non-opioid

Postoperative Pain Clinical Trial 2023: Acetaminophen 325Mg Tab Highlights & Side Effects. Trial Name: NCT03858231 — Phase 4

Acetaminophen 325Mg Tab (Non-Opioid Analgesic) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03858231 — Phase 4

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many participants are being recruited for this trial?

"Correct. According to clinicaltrials.gov, this medical research initiative was originally posted in October 2018 and has since been edited as recently as April of 2022. The study is currently seeking 300 participants from 1 trial site."

Answered by AI

Is this research endeavor presently open to new participants?

"Affirmative, the clinical trial's page on clinicaltrials.gov indicates that it is currently recruiting individuals for study participation. This medical trial was initially posted in October 2018 and recently modified April 2022; 300 subjects are needed from one location."

Answered by AI

Is it possible for me to be a part of this clinical exploration?

"This clinical trial is accepting applications from individuals between 18 and 80 years of age who are experiencing knee injuries. A total of 300 people will be enrolled to take part in the study."

Answered by AI

Does this scientific experiment accept volunteers over the age of 70?

"The age range for accepted participants in this trial is 18 to 80 years old."

Answered by AI

What maladies are often treated with Opioid medications?

"Opioid is frequently prescribed to manage catarrh, but it may also be used to alleviate rhinorrhoea and muscular pains as well as reduce muscle spasms."

Answered by AI

Can Opioid be administered to patients without adverse effects?

"The safety of Opioid was rated highly, at a 3 out of 3 due to the completion of Phase 4 trials which have been approved by our team at Power."

Answered by AI

Are there any analogous investigations that have employed Opioid in their methodology?

"At present, 1033 sites are conducting 109 ongoing Opioid clinical trials. From those studies, 32 have advanced to the third and final stage of testing. Pittsburgh is one of many cities that has launched a trial for this medication; however, other locations across the country are also investigating its efficacy."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Opioids Versus Non-Opioids Postoperative After Knee Arthroscopic Surgery

2018. "Opioids Versus Non-Opioids Postoperative After Knee Arthroscopic Surgery". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03858231.

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