Opioid for Knee Injuries

Phase-Based Progress Estimates
Sanford Health, Fargo, NDKnee Injuries+2 MoreNorco 5Mg-325Mg Tablet - Drug
18 - 80
All Sexes
What conditions do you have?

Study Summary

This trial will compare pain management with opioids versus non-opioids after knee surgery.

Eligible Conditions
  • Knee Injuries
  • Postoperative Pain
  • Opioid Use Disorder

Treatment Effectiveness

Effectiveness Progress

3 of 3
This is further along than 93% of similar trials

Study Objectives

2 Primary · 2 Secondary · Reporting Duration: baseline, 2 weeks, and 6 weeks post-operatively

Day 14
Change from Baseline Medication Use at 2 weeks
Week 2
Week 6
Change from Baseline Knee Injury and Osteoarthritis Outcome Score (KOOS) at 6 weeks
Change from Baseline Patient Reported Outcome Measurement Information System (PROMIS) at 6 weeks

Trial Safety

Safety Progress

3 of 3
This is further along than 85% of similar trials

Trial Design

2 Treatment Groups

1 of 2
1 of 2

Active Control

300 Total Participants · 2 Treatment Groups

Primary Treatment: Opioid · No Placebo Group · Phase 4

ActiveComparator Group · 1 Intervention: Norco 5Mg-325Mg Tablet · Intervention Types: Drug
Non-opioidActiveComparator Group · 2 Interventions: Acetaminophen 325Mg Tab, Ibuprofen 600 mg · Intervention Types: Drug, Drug

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: baseline, 2 weeks, and 6 weeks post-operatively

Who is running the clinical trial?

Sanford HealthLead Sponsor
44 Previous Clinical Trials
61,654 Total Patients Enrolled
Bruce Piatt, MDPrincipal InvestigatorSanford Health
1 Previous Clinical Trials
1 Total Patients Enrolled

Eligibility Criteria

Age 18 - 80 · All Participants · 2 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:

Frequently Asked Questions

How many participants are being recruited for this trial?

"Correct. According to clinicaltrials.gov, this medical research initiative was originally posted in October 2018 and has since been edited as recently as April of 2022. The study is currently seeking 300 participants from 1 trial site." - Anonymous Online Contributor

Unverified Answer

Is this research endeavor presently open to new participants?

"Affirmative, the clinical trial's page on clinicaltrials.gov indicates that it is currently recruiting individuals for study participation. This medical trial was initially posted in October 2018 and recently modified April 2022; 300 subjects are needed from one location." - Anonymous Online Contributor

Unverified Answer

Is it possible for me to be a part of this clinical exploration?

"This clinical trial is accepting applications from individuals between 18 and 80 years of age who are experiencing knee injuries. A total of 300 people will be enrolled to take part in the study." - Anonymous Online Contributor

Unverified Answer

Does this scientific experiment accept volunteers over the age of 70?

"The age range for accepted participants in this trial is 18 to 80 years old." - Anonymous Online Contributor

Unverified Answer

What maladies are often treated with Opioid medications?

"Opioid is frequently prescribed to manage catarrh, but it may also be used to alleviate rhinorrhoea and muscular pains as well as reduce muscle spasms." - Anonymous Online Contributor

Unverified Answer

Can Opioid be administered to patients without adverse effects?

"The safety of Opioid was rated highly, at a 3 out of 3 due to the completion of Phase 4 trials which have been approved by our team at Power." - Anonymous Online Contributor

Unverified Answer

Are there any analogous investigations that have employed Opioid in their methodology?

"At present, 1033 sites are conducting 109 ongoing Opioid clinical trials. From those studies, 32 have advanced to the third and final stage of testing. Pittsburgh is one of many cities that has launched a trial for this medication; however, other locations across the country are also investigating its efficacy." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.