Opioids vs Non-Opioids for Postoperative Pain After Knee Surgery
What You Need to Know Before You Apply
What is the purpose of this trial?
The purpose of this study is to look at pain management with opioids versus non-opioids after knee arthroscopy. This study will determine 1) whether the most commonly used non-narcotic medications provide pain relief comparable with the most commonly prescribed narcotic medications in patients undergoing arthroscopic knee surgery, and 2) whether patients' characteristics (gender, pre-operative knee symptoms, workers compensation status and employment status) affect pain level following surgery or medication usage.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but you cannot participate if you are taking certain blood thinners or medications that increase bleeding, except for low-dose aspirin (ASA 81mg).
Is it safe to use opioids and non-opioids like acetaminophen and ibuprofen for postoperative pain after knee surgery?
Acetaminophen (also known as paracetamol) and ibuprofen are generally considered safe for managing postoperative pain, with acetaminophen having a particularly safe profile. Combining these with opioids can reduce the amount of opioids needed, potentially lowering the risk of opioid-related side effects.12345
How does the drug acetaminophen and ibuprofen differ from other treatments for postoperative pain after knee surgery?
Acetaminophen and ibuprofen are non-opioid pain relievers that can reduce the need for opioids, which are often used for postoperative pain but can have significant side effects. This combination is part of a multimodal approach to pain management, offering a safer profile and potentially fewer side effects compared to opioid-only treatments.34678
What data supports the effectiveness of the drug for postoperative pain after knee surgery?
Research shows that acetaminophen (paracetamol) is effective for treating postsurgical pain and is often used in combination with opioids to enhance pain relief and reduce opioid side effects. Additionally, ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), has been shown to provide significant pain relief, with a lower number of patients needed to treat compared to paracetamol alone.13456
Who Is on the Research Team?
Bruce Piatt, MD
Principal Investigator
Sanford Health
Are You a Good Fit for This Trial?
This trial is for adults aged 18-80 undergoing elective knee arthroscopy, like meniscectomy or loose body removal. It's not for those with a history of chronic opioid use, significant medical issues in the past year, pregnant/nursing women, or anyone unable to consent. People on certain blood thinners or with active ulcers are also excluded.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive either opioid or non-opioid medications for pain management after knee arthroscopy
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Acetaminophen 325Mg Tab
- Ibuprofen 600 mg
- Norco 5Mg-325Mg Tablet
Acetaminophen 325Mg Tab is already approved in United States, European Union, Canada, Japan, China, Switzerland for the following indications:
- Pain relief
- Fever reduction
- Pain relief
- Fever reduction
- Pain relief
- Fever reduction
- Pain relief
- Fever reduction
- Pain relief
- Fever reduction
- Pain relief
- Fever reduction
Find a Clinic Near You
Who Is Running the Clinical Trial?
Sanford Health
Lead Sponsor