Intrathecal Morphine for Postoperative Pain
Trial Summary
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. However, if you are using certain medications like oral steroids or have conditions like chronic pain, you may not be eligible to participate.
What data supports the effectiveness of the drug for postoperative pain relief?
Is intrathecal morphine safe for humans?
How is the drug Morphine Sulfate used in intrathecal administration unique for postoperative pain management?
Intrathecal Morphine Sulfate is unique because it is administered directly into the spinal fluid, providing targeted pain relief with potentially lower doses compared to other methods, which can reduce the need for additional pain medication. This method can be particularly effective for managing postoperative pain, as it has been shown to significantly reduce pain scores and the requirement for extra analgesics.1371011
What is the purpose of this trial?
VATS is widely used for diagnosis and treatment of intrathoracic conditions. Despite many benefits, postoperative pain continues to be intense after VATS. The optimal strategy for pain management has not been defined. In this randomized, placebo-controlled, double-blinded clinical investigation, investigators hypothesize that 5 mcg/kg intrathecal morphine will decrease postoperative analgesic consumption and reduce pain.
Eligibility Criteria
This trial is for adults aged 18-80 undergoing elective lung surgery (VATS) with expected immediate recovery from anesthesia. Candidates must understand English and not have severe health issues like advanced organ diseases, drug or alcohol abuse, chronic pain conditions, or be on life support treatments.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive either intrathecal morphine or placebo during surgery
Follow-up
Participants are monitored for safety and effectiveness after treatment, including phone surveys at 1 and 3 months post-surgery
Treatment Details
Interventions
- Morphine Sulfate
- Placebo
Morphine Sulfate is already approved in United States, European Union, Canada for the following indications:
- Pain management
- Acute pain
- Chronic pain
- Cancer pain
- Severe pain
- Acute pain
- Chronic pain
- Cancer pain
- Pain management
- Acute pain
- Chronic pain
- Cancer pain
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Chicago
Lead Sponsor