200 Participants Needed

Regional Anesthesia vs Injection for Postoperative Pain

No Placebo GroupAll trial participants will receive the active study treatment (no placebo)
Prior Safety DataThis treatment has passed at least one previous human trial

Trial Summary

What is the purpose of this trial?

The purpose of the study is to compare two types of perioperative analgesic modalities, adductor canal block plus interspace between popliteal artery and capsule of the knee (IPACK) block and periarticular injection versus periarticular injection alone, to determine their relative efficacies with regard to pain relief and functional outcomes in the early postoperative period following primary total knee arthroplasty.

Research Team

AS

Andrew Schneider, MD

Principal Investigator

Washington University School of Medicine

Eligibility Criteria

This trial is for individuals undergoing knee replacement surgery who need pain management post-operation. Participants should be suitable for regional anesthesia and have no conditions that would interfere with the study.

Inclusion Criteria

Willing to sign informed consent
Willing to return for all follow-up visits
Having a smartphone or tablet device capable of running the FocusMotion platform
See 1 more

Exclusion Criteria

Preexisting functionally limiting neurologic disorders
I regularly use opioids, gabapentin, or pregabalin more than 5 days a week.
I am scheduled for surgery under general anesthesia.
See 7 more

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive either regional anesthesia (ACB + IPACK) and periarticular injection or periarticular injection alone

1 day
1 visit (in-person, day of surgery)

Postoperative Monitoring

Participants are monitored for pain relief and functional outcomes using VAS pain scores, step count, and other measures

2 weeks
Daily monitoring (virtual via app and Fitbit)

Follow-up

Participants are monitored for safety and effectiveness after treatment

2 weeks

Treatment Details

Interventions

  • Adductor Canal Block plus IPACK Block
  • Periarticular Injection
Trial Overview The study compares two pain relief methods after knee surgery: one group receives a nerve block plus an injection around the knee, while the other gets just the injection. The goal is to see which method better reduces pain and improves early movement.
Participant Groups
2Treatment groups
Active Control
Group I: Block and Periarticular injectionActive Control2 Interventions
regional anesthesia (Adductor canal block +IPACK) and Periarticular injection
Group II: Periarticular injectin aloneActive Control1 Intervention
Periarticular injection alone

Find a Clinic Near You

Who Is Running the Clinical Trial?

Washington University School of Medicine

Lead Sponsor

Trials
2,027
Recruited
2,353,000+
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