Suzetrigine vs Oxycodone for Postoperative Pain

Overseen By Libbee Galloway, MS

Age: 18+

Sex: Any

Trial Phase: Phase 4

Sponsor: University of Louisville

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Prior Safety Data This treatment has passed at least one previous human trial

Compensation: Varies

Number of Visits: Unknown

What You Need to Know Before You Apply

What is the purpose of this trial?

The purpose this study is determine whether postoperative oral dosage of suzetrigine is effective at controlling postoperative pain and reducing analgesic requirements following primary total knee arthroplasty (TKA) versus a control group of TKA patients receiving postoperative Oxycodone.

Who Is on the Research Team?

Rodolfo Zamora, MD

Principal Investigator

University of Louisville

Are You a Good Fit for This Trial?

Inclusion Criteria

I am between 21 and 89 years old.

I am scheduled for my first knee replacement on one knee due to osteoarthritis.

Patient agrees to participate as a study subject and signs the Informed Consent and Research Authorization document

Exclusion Criteria

Patient is unable to read and speak English

Contraindication or Hypersensitivity to suzetrigine

Pregnant or nursing females

What Are the Treatments Tested in This Trial?

Interventions

• Oxycodone
• Suzetrigine

How Is the Trial Designed?

Group I: Group A: suzetrigine group Experimental Treatment 1 Intervention

Participant will receive a two-week supply of oral suzetrigine upon discharge. Participant will also receive a 10-pill supply of Oxycodone as a rescue medication.

Group II: Group B: Oxycodone group Active Control 1 Intervention

Participant will receive a two-week supply of oral Oxycodone upon discharge

Who Is Running the Clinical Trial?

University of Louisville

Lead Sponsor

Trials

353

Recruited

76,400+