Dual Trigger IVF for OHSS
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial is testing a combination of two medications to improve egg quality in IVF for patients at high risk of complications. The goal is to retrieve more mature eggs without increasing the risk of OHSS.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
Is Dual Trigger IVF for OHSS safe for humans?
Research indicates that using a dual trigger approach in IVF, which involves a combination of medications like GnRH agonist and low dose hCG, can help prevent severe ovarian hyperstimulation syndrome (OHSS) in high-risk patients. While some cases of OHSS still occur, the studies suggest that this method is generally safe and can improve outcomes in IVF treatments.12345
How does the drug Pregnyl differ from other treatments for OHSS?
What data supports the effectiveness of the dual trigger IVF treatment for OHSS?
Who Is on the Research Team?
Miguel Russo, MD
Principal Investigator
Mount Sinai Hospital, Canada
Are You a Good Fit for This Trial?
This trial is for women aged 18-40 undergoing IVF with a risk of Ovarian Hyperstimulation Syndrome (OHSS). They must have at least 13 follicles or high estradiol levels on the day of trigger. Women who've had poor outcomes with dual triggers, low ovarian reserve, are preserving fertility due to cancer, have recurrent implantation failure, or certain medical conditions can't participate.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive a 'dual trigger' or placebo comparator followed by oocyte retrieval and embryo transfer
Follow-up
Participants are monitored for safety and effectiveness after embryo transfer, including assessment of pregnancy and live birth rates
Outcome Assessment
Assessment of live birth rate, OHSS incidence, and other secondary outcomes
What Are the Treatments Tested in This Trial?
Interventions
- Normal Saline
- Pregnyl
Find a Clinic Near You
Who Is Running the Clinical Trial?
Mount Sinai Hospital, Canada
Lead Sponsor