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Rho Kinase Inhibitor

Netarsudil vs Brimonidine for Normal Tension Glaucoma

Phase 4
Led By Zarmeena Vendal, MD
Research Sponsored by Westlake Eye Specialists
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Diagnosed with normal tension glaucoma based on the following: IOP ≤ 21mmHg, Optic nerve rim thinning and/or retinal nerve fiber layer (RNFL) loss consistent with glaucoma, Normal visual field OR visual field loss consistent with optic nerve or RNFL defects within the last year, Open angles assessed by gonioscopy, Have been on latanoprost monotherapy for at least 6 weeks
Be older than 18 years old
Must not have
Other forms of secondary glaucoma
Patients with angle closure glaucoma or secondary forms of glaucoma due to neovascularization of the angle, uveitic glaucoma, congenital glaucoma, or glaucoma due to congenital anomalies
Screening 3 weeks
Treatment Varies
Follow Up after 6 weeks of treatment
Awards & highlights


This trial will compare the effects of adding netarsudil or brimonidine to the eye drops of patients with glaucoma who are already using latanoprost. The study will measure changes

Who is the study for?
This trial is for patients with Normal Tension Glaucoma (NTG) who are already using latanoprost. Participants should be stable on their current treatment and available for a screening visit and at least one follow-up. Specific inclusion or exclusion criteria were not provided.Check my eligibility
What is being tested?
The study compares the effect of adding netarsudil versus brimonidine to NTG patients' existing latanoprost regimen on intraocular pressure (IOP). It's a randomized, multicenter trial where participants won't know which additional medication they're receiving.See study design
What are the potential side effects?
Possible side effects of netarsudil include eye redness, cornea deposits, and allergy symptoms. Brimonidine may cause dry mouth, fatigue, or allergic reactions. Side effects can vary based on individual patient response.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
I have normal tension glaucoma and have been on latanoprost for 6 weeks.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
I have a type of glaucoma that is not primary.
I have a specific type of glaucoma not caused by high eye pressure alone.
I am an adult without cognitive impairments and not critically ill.
I am allergic to or have not responded to brimonidine or netarsudil.
I have had surgery for glaucoma.
My eye swelling has not improved for 3 months or more.


Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~after 6 weeks of treatment
This trial's timeline: 3 weeks for screening, Varies for treatment, and after 6 weeks of treatment for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Mean diurnal intraocular pressure
Secondary outcome measures
Mean intraocular pressure at 12pm
Mean intraocular pressure at 4pm
Mean intraocular pressure at 8am
+1 more

Side effects data

From 2019 Phase 3 trial • 120 Patients • NCT03248037
Ocular irritation considered related to study drug use
Air re-injection
Study treatment Arm

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: NetarsudilExperimental Treatment1 Intervention
netarsudil 0.02%
Group II: BrimonidineActive Control1 Intervention
brimonidine 0.1%
First Studied
Drug Approval Stage
How many patients have taken this drug
Completed Phase 3

Find a Location

Who is running the clinical trial?

Westlake Eye SpecialistsLead Sponsor
SengiIndustry Sponsor
20 Previous Clinical Trials
1,559 Total Patients Enrolled
Zarmeena Vendal, MDPrincipal InvestigatorWestlake Eye Specialists
~67 spots leftby Jun 2025