Revanesse® Renew™+ for Wrinkles
What You Need to Know Before You Apply
What is the purpose of this trial?
Revanesse® Renew™+ (Prollenium Medical Technologies Inc.) is a non-crosslinked HA skin booster that combines low- and high-molecular-weight HA at a concentration of 14 mg/mL in a sterile aqueous gel for intradermal injection7. This dual-weight formulation provides both rapid hydration and sustained moisture retention, improving dermal suppleness and promoting subtle textural refinement through physiologic hydration rather than volumization.
The present study is designed to compare biweekly and monthly treatment schedules of Revanesse® Renew™+, assessing clinical efficacy, objective biophysical markers, and participant-reported outcomes to inform evidence-based treatment protocols in aesthetic medicine.
Who Is on the Research Team?
Andreas Nikolis, MD, PhD
Principal Investigator
Erevna Innovations Inc.
Are You a Good Fit for This Trial?
This trial is for immune-competent adults over 30 who want to improve their facial skin quality. Participants must understand the study, consent to it, and follow pre-visit instructions like shaving. Women of childbearing age must use effective birth control and take pregnancy tests.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive Revanesse® Renew™+ injections either biweekly or monthly for a total of three treatments
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Revanesse® Renew™+
Trial Overview
The study tests Revanesse® Renew™+, a dual-weight hyaluronic acid gel injected into the skin to hydrate and refine texture without adding volume. It compares treatment schedules (biweekly vs monthly) for effectiveness in enhancing facial aesthetics.
How Is the Trial Designed?
2
Treatment groups
Active Control
Participants randomized to Group 1 : Biweekly Treatment, will undergo three treatments with Revanesse (R) Renew(TM)+ spaced 2 weeks apart.
Participants randomized to Group 2: Monthly Treatment, will undergo three treatments with Revanesse (R) Renew(TM)+ spaced 4 weeks apart.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Erevna Innovations Inc.
Lead Sponsor
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