Study Summary
This trial will study whether two doses of Jynneos given four weeks apart can create an immunity response, and whether taking Tpoxx or placebo orally twice a day for 28 days interferes with this response.
Treatment Effectiveness
Effectiveness Progress
Study Objectives
1 Primary · 1 Secondary · Reporting Duration: Day 43
Trial Safety
Safety Progress
Trial Design
2 Treatment Groups
JYNNEOS + TPOXX
1 of 2
JYNNEOS + matching TPOXX placebo
1 of 2
Active Control
Non-Treatment Group
100 Total Participants · 2 Treatment Groups
Primary Treatment: JYNNEOS + TPOXX · Has Placebo Group · Phase 2
Trial Logistics
Trial Timeline
Who is running the clinical trial?
Eligibility Criteria
Age 18 - 42 · All Participants · 10 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:Frequently Asked Questions
What is the participant capacity for this experiment?
"Affirmative. The data hosted on clinicaltrials.gov attests that this research is currently seeking participants, as it was initially posted on the 5th of January 2022 and updated lastly 10/6/2022. A total of 100 individuals are required between 2 different medical centres for the trial to take place." - Anonymous Online Contributor
Have other experiments featured the combination of JYNNEOS and TPOXX?
"Currently, 3 trials for the combination of JYNNEOS and TPOXX are being conducted with 1 at Phase 3. Most studies take place in Omaha, Nebraska, though 12 other sites are running tests as well." - Anonymous Online Contributor
Are there any hazardous risks associated with using JYNNEOS + TPOXX?
"The safety of JYNNEOS + TPOXX has been rated a 2 on the risk-assessment scale. This is due to Phase 2 trial data confirming basic safety, though there are presently no verifications that it can be effective in treating symptoms." - Anonymous Online Contributor
Is this an unprecedented research endeavor?
"Since 2022, SIGA Technologies have been researching JYNNEOS + TPOXX. This medicinal combination was granted Phase 2 approval following a 100 person trial in the same year, and since then three separate studies are occurring across nine cities and one nation." - Anonymous Online Contributor
Does this experiment include participants who are over two decades old?
"This clinical research is seeking subjects aged between 18 and 42 years old." - Anonymous Online Contributor
Is this trial currently open to participants?
"Affirmative. Clinicaltrials.gov documents reveal that this clinical study, which was first posted on May 1st 2022, is still seeking participants. Approximately 100 subjects need to be enrolled from two distinct medical centers." - Anonymous Online Contributor
Would I fulfill the requirements to join this research study?
"This trial seeks 100 healthy adults between 18 and 42 years of age who have been diagnosed with smallpox. In addition to this, potential participants must possess a resting heart rate above 40 beats per minute or below 110 bpm; be HIV antibody-, hepatitis B surface antigen- and hepatitis C virus antibody negative; have white blood cells ranging from 2500/mm3 to 11 000/mm3; hemoglobin within normal limits; platelets at or greater than the lower reference range for laboratory results; calculated creatinine clearance over 60 mL/min as estimated by the Cockcroft-Gault equation; creatinine in males ≤1.7" - Anonymous Online Contributor