Apabetalone for Pulmonary Arterial Hypertension
(APPROACH-2 Trial)
Trial Summary
What is the purpose of this trial?
This trial tests a new pill that may help reduce the severity of Pulmonary Arterial Hypertension (PAH) and improve heart and lung function in adults who are already on stable treatment.
Research Team
Steeve Provencher, MD
Principal Investigator
IUCPQ-UL
Pascale Blais-Lecours, PhD
Principal Investigator
IUCPQ-UL
Eligibility Criteria
Adults aged 18-75 with Pulmonary Arterial Hypertension (PAH) who are stable on current PAH medication for at least 3 months can join. They must be able to walk at least 150 meters and have a life expectancy of more than 28 weeks. Participants need normal organ function, not be pregnant or breastfeeding, and agree to use contraception if necessary.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Pre-treatment
A 4-week pre-treatment phase to ensure patients are on stable doses of PAH medication
Treatment
Participants receive apabetalone 100mg BID or placebo for 24 weeks
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Apabetalone
Find a Clinic Near You
Who Is Running the Clinical Trial?
Institut universitaire de cardiologie et de pneumologie de Québec, University Laval
Lead Sponsor
Laval University
Lead Sponsor
Resverlogix Corp
Industry Sponsor
Canadian Institutes of Health Research (CIHR)
Collaborator