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N-Acetyl Cysteine for Gulf War Syndrome (NAC Trial)
NAC Trial Summary
This trial will test if N-acetyl cysteine (NAC) can help reduce symptoms in Gulf War Illness (GWI) by reducing oxidative stress and boosting antioxidants.
NAC Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowNAC Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.NAC Trial Design
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Who is running the clinical trial?
Media Library
- I do not have chronic infections like HIV, HBV, or HCV.I have conditions like high blood pressure or diabetes, but they are well-managed.I have had surgery within the last 6 weeks or will have surgery during the study.I am currently receiving dialysis.I have a bleeding disorder or take blood thinners.I have taken stavudine or didanosine for over a week in the last month.My kidney function is impaired with a creatinine level over 2.0 mg/dL.I have a diagnosis that explains my severe fatigue.I am between 47 and 70 years old.I do not have severe liver disease.My diabetes is under control, or I am receiving proper care for it.I have PTSD, MDD, or mild TBI but haven't been hospitalized for it in the last 2 years.I have not taken antiviral medications like interferon or ribavirin in the last 30 days.I have not taken any herbal medicine in the last 30 days.I am between 47 and 70 years old.I have been diagnosed with a heart or blood vessel disease.
- Group 1: Placebo
- Group 2: N-Acetyl Cysteine (NAC)
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
How many locations are actively participating in this experimentation?
"Six medical sites are recruiting patients for this trial, including RTI International in Durham, Nova Southeastern University in Fort Lauderdale and VA New jersey Health Care System War Related Illness and Injury Study Center in East Orange. Additionally, three other facilities are also participating."
What is the overarching objective of this medical experiment?
"The primary goal of the trial, which will span approximately 12 weeks, is to gauge glutathione levels. Secondary objectives include a review of treatment-related side effects based on safety questionnaires filled out at baseline and 8 week intervals; additionally, there is an assessment regarding the protection offered by intervention over time."
How many participants are currently involved in this clinical research endeavor?
"At the current moment, no additional patients are being sought out for this trial. The original post date was October 1st 2022 and subsequent updates were made until August 1st 2022. If you're still interested in participating in medical trials, there exist 6 studies which require individuals with Gulf War Syndrome as well as 24 more involving N-Acetyl Cysteine (NAC)."
Who is eligible to be involved in this research endeavor?
"This medical trial seeks 170 veterans of the Gulf War aged 47-70 to participate. Participants should have been present in the theatre between August 1990 and July 1991 and can possess comorbidities such as PTSD, MDD, or mTBI (severe TBI excluded). Furthermore, all volunteers must exhibit stable health indices throughout screening, give written consent for participation in follow up visits, and agree to allow normal illnesses associated with aging if they are being successfully treated prior to recruitment."
Does the research study include geriatric participants?
"The age limitation for this trial are between 47 and 70 years old, as per the study's inclusion criteria."
Are more participants being accepted for this trial at present?
"Regrettably, per the information on clinicaltrials.gov this research is no longer recruiting participants since it was initially posted in October of 2022 and last edited in August of 2022. Nevertheless, there are presently 30 other trials actively looking for individuals to join them."
Could you elaborate on the research that has been conducted with N-Acetyl Cysteine (NAC)?
"N-Acetyl Cysteine (NAC) first appeared in the medical sphere at Suleyman Demirel University in 2013, and since then 18364 studies have been concluded. As of now, 24 active clinical trials are running; many taking place out of Durham, North carolina."
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