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FOLFIRINOX for Pancreatic Cancer
Study Summary
This trial will enroll patients with resectable or borderline resectable PDAC who will receive FOLFIRINOX as neoadjuvant therapy (chemotherapy given before surgery).
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- I am considered fit for surgery to remove pancreatic cancer by a surgeon.I have not had chemotherapy, chemoradiotherapy, or surgery for pancreatic cancer.My organs are functioning well enough for me to join the study.I am allergic to certain chemotherapy drugs like 5FU, oxaliplatin, or irinotecan.I am 18 years old or older.I have not had major surgery or a significant injury in the last 4 weeks.My pancreatic cancer is confirmed and has not spread to distant parts of my body.I can carry out all my usual activities without help.I agree to have biopsies of my pancreatic mass before and after treatment.My pancreatic cancer is advanced but hasn't been removed by surgery.I have a known DPD enzyme deficiency.I am a woman who can have children and have had a negative pregnancy test in the last 14 days.I haven't had cancer in the last 5 years, except for certain skin, cervical, or bladder cancers.I experience significant numbness or pain in my hands or feet.I cannot or will not stop taking ketoconazole or St John's wort.I agree to use effective birth control during and for 8 weeks after the study.My pancreatic cancer has returned or spread.
- Group 1: SingleArm: FOLFIRINOX
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
What are some of the short-term side effects associated with taking Oxaliplatin?
"While there is some data suggesting that Oxaliplatin is safe, it did not receive a higher score because Phase 2 trials lack efficacy data."
Can new patients still join this trial?
"That is accurate. The website clinicaltrials.gov has the most recent information on this trial, which was posted June 12th, 2019 and edited June 8th, 2020. This study is looking for 45 individuals at a single site."
What are some other examples of research done with Oxaliplatin?
"There are a total of 676 studies investigating oxaliplatin. 207 of these studies are clinical trials that are currently ongoing. While the majority of these trials originated in Guangzhou, Guangdong, there are 28744 locations worldwide where patients can receive this treatment as part of a trial."
What are the enrolment requirements for this medical study?
"This clinical trial is admitting 45 patients with cancer of the pancreas between the ages of 18 and 99. Most notable, applicants should meet the following criteria: have not received prior chemotherapy or chemoradiotherapy for pancreatic cancer, have not had surgery to remove pancreatic cancer, be in good physical health as determined by ECOG performance status 0 or 1., have no evidence of co-morbidities precluding the potential to undergo surgical resection of PDAC as determined by surgical investigator., and have measurable or non-measurable but evaluable (as determined by Response Evaluation Criteria in Solid Tumors version 1."
How many individuals are being given this medication as part of the trial?
"The clinical trial is still admitting patients and was originally posted on 6/12/2019. The most recent update was on 6/8/2022. 45 participants are needed and 1 site is sufficient."
For this particular experiment, are elders welcome to participate?
"The age range for participants in this trial is 18 to 99 years old."
For what illnesses is Oxaliplatin most commonly prescribed?
"Oxaliplatin is most often used to treat rectal carcinoma, but it can also be effective in fighting other forms of cancer like colorectal carcinoma, ovarian cancer, and sarcoma."
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