SMART for Pancreatic Cancer
What You Need to Know Before You Apply
What is the purpose of this trial?
High-dose magnetic resonance imaging (MRI) guided hypofractionated radiation therapy delivered using daily adaptive dose planning has been shown in a retrospective study to result in improved overall survival, relative to patients receiving lower radiation doses, in patients with locally advanced pancreatic cancer, without increasing the rate of serious gastrointestinal toxicity.The goal of the proposed trial is to investigative in a controlled, prospective manner the robustness of this outcome, and to track quality of life over a 5-year trial period.
Do I need to stop my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
Is SMART generally safe for humans?
How is the SMART treatment for pancreatic cancer different from other treatments?
SMART (Stereotactic MRI-guided On-table Adaptive Radiation Therapy) is unique because it uses real-time MRI guidance to precisely target pancreatic tumors with high-dose radiation, even when they are close to sensitive organs. This allows for safer delivery of effective doses compared to traditional radiation therapies, which can be limited by the proximity of vital organs.12356
What data supports the effectiveness of the treatment Stereotactic MRI-guided On-table Adaptive Radiation Therapy (SMART) for pancreatic cancer?
Research shows that SMART can deliver high doses of radiation precisely to pancreatic tumors, even when they are close to sensitive organs, which is important for treating inoperable pancreatic cancer. Studies have reported benefits from daily adaptation of the treatment, suggesting it can be effective and safe for patients.12356
Who Is on the Research Team?
Michael Chuong, MD
Principal Investigator
Miami Cancer Institute
Parag Parikh, MD
Principal Investigator
Henry Ford Health System
Daniel Low, PhD
Principal Investigator
University of California, Los Angeles
Percy Lee, MD
Principal Investigator
MD Anderson
Are You a Good Fit for This Trial?
This trial is for adults with advanced pancreatic cancer that can't be surgically removed. They must have had at least 3 months of chemotherapy, be in good physical condition, and have normal organ/blood function. Pregnant or breastfeeding individuals, those with distant metastatic disease, high CA19.9 levels, recent major surgery, uncontrolled illnesses or a history of certain treatments are excluded.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive stereotactic MRI-guided on-table adaptive radiation therapy, 50 Gy in 5 fractions
Follow-up
Participants are monitored for grade 3 or higher gastrointestinal toxicity and overall survival
Long-term Follow-up
Participants' overall survival and quality of life are assessed at 2 years and 12 months post-treatment
What Are the Treatments Tested in This Trial?
Interventions
- Stereotactic MRI-guided On-table Adaptive Radiation Therapy (SMART)
Find a Clinic Near You
Who Is Running the Clinical Trial?
Viewray Inc.
Lead Sponsor