Tirzepatide + Exercise for Obesity
(EXER-MED Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This is clinical trials is to evaluate the effect of exercise with weight loss medication compared to weight loss alone. The study will enroll 24 adults from 30-65 years old with overweight or obesity.
The main questions it will answer includes:
* Does exercise combined with weight loss medication reduce body weight and body fat more than weight loss medication alone
* Does exercise combined with weight loss medication improve other risk factors more such as the sugar in the blood, cholesterol, fitness, and quality of life
Participants will:
* Take a weight loss medication (tirzepatide) monthly under the supervision of their primary care physician
* (Exercise group only) Will perform exercise \~3 times a week at the University of Virginia). Walking on a treadmill and resistance training
* Visit the study site at the beginning of the study and after the study to evaluate weight, body fat, and other health measures
Who Is on the Research Team?
Damon L Swift, Ph.D
Principal Investigator
University of Virginia
Are You a Good Fit for This Trial?
Adults aged 30-65 with obesity or overweight and additional heart-related risk factors can join this trial. They must be healthy enough for weight loss medication, willing to consent, and have their doctor's approval.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive tirzepatide monthly and engage in exercise (for the exercise group) for 16 weeks
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Exercise
- Tirzepatide
Trial Overview
The study tests if exercise combined with the weight loss drug Tirzepatide is more effective than the drug alone in reducing body weight/fat and improving blood sugar, cholesterol levels, fitness, and quality of life.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Active Control
Participants will perform aerobic and resistance exercise while taking monthly tirzepatide for 16 weeks
Participants will take monthly Tirzepatide under the care of their primary care provider for 16 weeks
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Virginia
Lead Sponsor
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