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Nonsteroidal Anti-inflammatory Drug

Aspirin for Acoustic Neuroma

Phase 2
Recruiting
Led By Konstantina Stankovic, MD, PhD
Research Sponsored by Massachusetts Eye and Ear Infirmary
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Age≥12 years
Ability to swallow tablets
Timeline
Screening 3 weeks
Treatment Varies
Follow Up progression, or around 3.5 years
Awards & highlights

Study Summary

This trial will test whether aspirin can help patients with a type of cancer called Vestibular Schwannoma by either slowing down tumor growth or maintaining/improving hearing.

Who is the study for?
This trial is for individuals aged 12 or older with a type of benign brain tumor called vestibular schwannoma, which can affect hearing. Participants must be able to swallow tablets and give informed consent; children need parental consent as well. People using daily aspirin, those allergic to it, pregnant women, and patients with severe illnesses like asthma or conditions affecting MRI scans cannot join.Check my eligibility
What is being tested?
The study is testing if aspirin can slow down the growth of vestibular schwannomas and help maintain or improve hearing in affected patients. It's a phase II trial where participants are randomly assigned to receive either aspirin or a placebo without knowing which one they're getting.See study design
What are the potential side effects?
Aspirin may cause side effects such as stomach upset, increased risk of bleeding, allergic reactions in some people, and possibly breathing difficulties in those with asthma.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am 12 years old or older.
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I can swallow pills.
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I have a tumor on my hearing and balance nerve, confirmed by imaging.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~progression, or around 3.5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and progression, or around 3.5 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Progression Free Survival

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: AspirinExperimental Treatment1 Intervention
Patients on the experimental arm will receive blinded aspirin. Pediatric subjects who weigh less than 110 lbs will take 81mg aspirin twice a day. All other subjects will take 325mg aspirin twice a day.
Group II: PlaceboPlacebo Group1 Intervention
Patients on the placebo arm will receive blinded placebo and take it twice a day.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Aspirin
2014
Completed Phase 4
~55580

Find a Location

Who is running the clinical trial?

United States Department of DefenseFED
859 Previous Clinical Trials
225,331 Total Patients Enrolled
Massachusetts General HospitalOTHER
2,924 Previous Clinical Trials
13,193,123 Total Patients Enrolled
Massachusetts Eye and Ear InfirmaryLead Sponsor
106 Previous Clinical Trials
12,649 Total Patients Enrolled

Media Library

Aspirin (Nonsteroidal Anti-inflammatory Drug) Clinical Trial Eligibility Overview. Trial Name: NCT03079999 — Phase 2
Acoustic Neuroma Research Study Groups: Aspirin, Placebo
Acoustic Neuroma Clinical Trial 2023: Aspirin Highlights & Side Effects. Trial Name: NCT03079999 — Phase 2
Aspirin (Nonsteroidal Anti-inflammatory Drug) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03079999 — Phase 2

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are people with the required qualifications able to join this clinical trial at its current stage?

"According to the government website that tracks this information, this clinical trial is still looking for patients. The posting went up on 6/11/2018 and was last edited on 6/23/2022."

Answered by AI

What is the most well-known ailment that Aspirin can help alleviate?

"Aspirin is a medication with many applications. It can be used to treat dental procedures, inflammation, neck pain, and percutaneous coronary intervention (pci)."

Answered by AI

Are there similar cases to this Aspirin study?

"Aspirin was originally studied in 2002 at Institut Curie Hopital. Since then, there have been a total of 18727 completed trials on the medication. Currently, 181 clinical trials are active, with many of them taking place in Salt Lake City, Utah."

Answered by AI

Does Aspirin carry any life-threatening risks for patients?

"While there is some data supporting aspirin's safety, it has not been proven effective yet and so it receives a score of 2."

Answered by AI

Can you give me a breakdown of where this trial is taking place?

"Currently, there are six sites across the United States recruiting patients for this trial. These include locations in Salt Lake City, Miami, and Rochester."

Answered by AI

How many people can enroll in this trial at most?

"That is correct. The table on clinicaltrials.gov suggests that this study, which was first posted on 6/11/2018, is still looking for enrollees. They need 300 patients in total from 6 different sites."

Answered by AI

What is unique about this clinical trial?

"As of today, there are 181 active studies being conducted for aspirin across 1451 cities and 61 countries. This research began in 2002 with an initial study involving 413 participants that was sponsored by Sanofi."

Answered by AI
~59 spots leftby Sep 2025