Palliative radiotherapy for Neoplasm Metastasis

Phase-Based Progress Estimates
1
Effectiveness
2
Safety
Memorial Sloan Kettering Bergen (All protocol activities), Montvale, NJ
Neoplasm Metastasis+1 More
Palliative radiotherapy - Radiation
Eligibility
18+
All Sexes
Eligible conditions
Select

Study Summary

This study is evaluating whether a lower dose of radiation is effective for treating tumors with an ATM mutation.

See full description

Eligible Conditions

  • Neoplasm Metastasis
  • Metastatic Cancers

Treatment Effectiveness

Effectiveness Progress

1 of 3

Other trials for Neoplasm Metastasis

Study Objectives

This trial is evaluating whether Palliative radiotherapy will improve 1 primary outcome in patients with Neoplasm Metastasis. Measurement will happen over the course of 6 month.

6 month
Treatment failure rate of irradiated lesion

Trial Safety

Safety Progress

2 of 3
This is further along than 68% of similar trials

Other trials for Neoplasm Metastasis

Trial Design

1 Treatment Group

radiation
1 of 1
Experimental Treatment

This trial requires 58 total participants across 1 different treatment group

This trial involves a single treatment. Palliative Radiotherapy is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 2 and have already been tested with other people.

radiation
Radiation
Subjects will receive reduced dose radiation to radiographically progressive lesions identified on imaging (including asymptomatic bone metastases).
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Palliative radiotherapy
2015
Completed Phase 2
~10

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 6 month
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly 6 month for reporting.

Closest Location

Memorial Sloan Kettering Bergen (All protocol activities) - Montvale, NJ

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There are 7 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
A cancer that has been confirmed by a medical examination to have spread to other parts of the body and is therefore not curable is referred for palliative radiotherapy. show original
No evidence of disease The patient has no evidence of disease and a performance status of 0-2. show original
At least 18 years old. show original
Able to make a well-informed decision. show original
Patients who are able to have children must agree to use an effective birth control method while they are receiving radiation treatments. show original
The person can expect to live for at least six more months. show original
Pathogenic mutations in ATM (somatic and germline allowed) can result in several diseases, including ataxia telangiectasia, breast cancer, and ovarian cancer. show original

Patient Q&A Section

Does neoplasm metastasis run in families?

"Neoplasms are the second leading source of deaths in children after accidents, injuries, and burns. In the future, we will need to develop a better understanding of cancer genetics so that appropriate preventive measures can be implemented." - Anonymous Online Contributor

Unverified Answer

What is palliative radiotherapy?

"Palliative radiotherapy has been widely used in the management of a variety of tumors and conditions. While many patients believe that radiotherapy reduces pain and improves quality of life, this does not seem to be supported by the evidence. Patients should ask their physicians how much radiotherapy they will receive to help them make an informed decision about therapy." - Anonymous Online Contributor

Unverified Answer

What does palliative radiotherapy usually treat?

"In a recent study, we found that the majority of patients treated (88%) received palliative RT for local control. The usual area(s) of involvement were bones and spine. Radiation therapy was also frequently used for pain relief, especially in patients with neurologic symptoms. The main reasons for non-use of RT were lack of response to the initial treatment regimen and patient preference." - Anonymous Online Contributor

Unverified Answer

How quickly does neoplasm metastasis spread?

"Data from a recent study of this study suggest that the time from surgery to metastasis is not related to tumor size. Furthermore, metastasis may occur at any time during the follow-up period, regardless of tumor size. Therefore, the determination of metastatic dissemination seems to be a random event in this disease." - Anonymous Online Contributor

Unverified Answer

Does palliative radiotherapy improve quality of life for those with neoplasm metastasis?

"Recent findings showed that palliative RT was associated with better QOL than no RT. Future well-designed randomized controlled trials should include assessments of QOL to provide evidence for the benefit of palliative RT." - Anonymous Online Contributor

Unverified Answer

How does palliative radiotherapy work?

"Palliative RT improves pain and QOL compared with other treatments; however, it has no impact on OS. In particular, as the disease progresses, locoregional control is significantly improved whereas distant metastasis is unaffected." - Anonymous Online Contributor

Unverified Answer

Has palliative radiotherapy proven to be more effective than a placebo?

"RT is an effective and well tolerated treatment for patients with unresectable distant cancer, especially when administered during the palliative period. Recent findings suggest that RT should be considered as one of the possible therapeutic options in advanced cancer patients." - Anonymous Online Contributor

Unverified Answer

Can neoplasm metastasis be cured?

"In specific cases it is possible to achieve complete remission of metastatic lesions after surgical treatment. On the basis of our short follow up this approach can be recommended only on the basis of a clinical assessment." - Anonymous Online Contributor

Unverified Answer

Have there been other clinical trials involving palliative radiotherapy?

"Radiotherapy has been an effective treatment for many malignant tumors and has contributed to the survival of hundreds of thousands of people worldwide. Although palliative radiotherapy is no longer used routinely for treating solid tumors, it remains an important tool in the management of advanced cancer." - Anonymous Online Contributor

Unverified Answer

How many people get neoplasm metastasis a year in the United States?

"Although neoplasm metastasis is uncommon, it still occurs and can be fatal. For example, in the U.S., [12,000 people per year die from metastatic [colorectal cancer](https://www.withpower.com/clinical-trials/colorectal-cancer)] because of poor prognosis and insufficient treatment.[current cancer treatment]." - Anonymous Online Contributor

Unverified Answer

Who should consider clinical trials for neoplasm metastasis?

"Clinical trials on cancer patients seem to be worthwhile, even if they do not show any significant effect on survival. Patients with metastatic disease are more likely to benefit from clinical trials. However, this risk must be balanced against the risks of toxicity and costs. Careful patient selection and adequate consent procedures are mandatory before starting any cancer drug studies." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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