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Radiation Therapy

Palliative Radiotherapy for Cancer

Phase 2
Led By Amy Xu, MD, PhD
Research Sponsored by Memorial Sloan Kettering Cancer Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
ECOG performance status 0-2
Histologically confirmed malignancy with at least one metastatic lesion referred for palliative radiotherapy
Screening 3 weeks
Treatment Varies
Follow Up 6 month
Awards & highlights

Study Summary

This trial will test a lower dose of radiation to see if it is still effective against cancer that has spread and has an ATM mutation.

Who is the study for?
This trial is for adults over 18 with a life expectancy of at least 6 months who have cancer that has spread and shows a specific genetic change (ATM mutation). They should be able to undergo reduced-dose radiation therapy, not previously treated in the same area, and must agree to use effective contraception.Check my eligibility
What is being tested?
The study is examining if lower doses of radiation can still effectively treat metastatic tumors with an ATM mutation. It aims to determine the minimum effective dose of palliative radiotherapy for these patients.See study design
What are the potential side effects?
While not specified here, common side effects from reduced-dose radiation may include skin irritation, fatigue, mild swelling or pain around the treatment area. The severity often depends on individual patient factors.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
I can take care of myself and perform daily activities.
My cancer has spread, and I am referred for symptom relief radiation.
I am 18 years old or older.
I have a genetic mutation in the ATM gene.


Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 month
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 month for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Treatment failure rate of irradiated lesion

Trial Design

1Treatment groups
Experimental Treatment
Group I: radiationExperimental Treatment1 Intervention
Subjects will receive reduced dose radiation to radiographically progressive lesions identified on imaging (including asymptomatic bone metastases).
First Studied
Drug Approval Stage
How many patients have taken this drug
Palliative radiotherapy
Completed Phase 2

Find a Location

Who is running the clinical trial?

Memorial Sloan Kettering Cancer CenterLead Sponsor
1,933 Previous Clinical Trials
585,591 Total Patients Enrolled
Amy Xu, MD, PhDPrincipal InvestigatorMemorial Sloan Kettering Cancer Center
2 Previous Clinical Trials
185 Total Patients Enrolled

Media Library

Palliative radiotherapy (Radiation Therapy) Clinical Trial Eligibility Overview. Trial Name: NCT05010031 — Phase 2
Cancer Research Study Groups: radiation
Cancer Clinical Trial 2023: Palliative radiotherapy Highlights & Side Effects. Trial Name: NCT05010031 — Phase 2
Palliative radiotherapy (Radiation Therapy) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05010031 — Phase 2

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

To what degree is Palliative radiotherapy innocuous for patients?

"There is some evidence of Palliative radiotherapy's safety, thus it was assigned a rating of 2. It should be noted that there are no clinical studies to corroborate effectiveness yet."

Answered by AI

To which locations is this research being conducted?

"Seven locations are hosting patient recruitment for this trial: Harrison, Middletown and New york amongst others. It is advisable that participants choose the location nearest them to minimize their commute when taking part in the experiment."

Answered by AI

Are participants currently being invited to partake in this clinical experiment?

"Affirmative. Clinicaltrials.gov provides evidence that this clinical study is currently recruiting participants, having first been posted on August 11th 2021 and last updated September 23rd 2022."

Answered by AI

What is the scope of patients participating in this research?

"True, the clinical trial is currently open for enrollment. The study was originally published on August 11th 2021 and most recently updated on September 23rd 2022. A total of 58 individuals are needed to participate across 7 different medical sites."

Answered by AI
~13 spots leftby Aug 2026