NAC + Mindfulness-Based Cognitive Therapy for Depression
(NAC+MIND Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
The primary goal is to investigate to what extent changes in glutamate and glutathione modulation and functional integration between brain networks associated with emotion and attention regulation are associated with treatment response in mildly depressed youth.
Are You a Good Fit for This Trial?
Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive N-acetylcysteine and/or mindfulness-based cognitive therapy over 8 weeks
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Mindfulness-based cognitive therapy
- N-acetylcysteine
How Is the Trial Designed?
4
Treatment groups
Experimental Treatment
Active Control
Placebo Group
Placebo capsules daily and sham mindfulness-based intervention over 8 weeks
N-acetylcysteine 2400 mg daily and mindfulness-based cognitive therapy over 8 weeks
Placebo capsules and mindfulness-based cognitive therapy over 8 weeks
N-acetylcysteine 2400 mg daily and sham mindfulness-based intervention over 8 weeks
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Cincinnati
Lead Sponsor
National Center for Complementary and Integrative Health (NCCIH)
Collaborator
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